نتایج جستجو برای: excitatory amino acids

تعداد نتایج: 358563  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1989
G Gerber I Kangrga P D Ryu J S Larew M Randic

Spinal cord slice preparation and intracellular recording techniques were used to examine the effects of phorbol esters on the sodium- and calcium-dependent action potentials, the excitatory synaptic transmission, the basal (resting) and the dorsal root stimulation-evoked release of 9 endogenous amino acids, including glutamate and aspartate, and the responsiveness of the rat dorsal horn neuron...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
S Sugita N Uchimura Z G Jiang R A North

Intracellular recordings were made from neurons of rat lateral amygdala, nucleus accumbens, and striatum in vitro. Synaptic potentials mediated by gamma-aminobutyric acid and by excitatory amino acids were isolated pharmacologically by using receptor antagonists, and their amplitudes were used as a measure of transmitter release. Muscarine and acetylcholine inhibited the release of both gamma-a...

Journal: :Acta neurobiologiae experimentalis 1993
H Shinozaki M Ishida

The 2S,3S,4S-isomer (L-CCG-I) of 2-(carboxycyclopropyl)glycine (CCG) is a potent metabotropic glutamate receptor agonist. L-CCG-I depressed monosynaptic excitation in the newborn rat spinal motoneurone at low concentrations well below those causing postsynaptic depolarization. 2S,3R,4S-CCG (L-CCG-IV) is a potent N-methyl-D-aspartate (NMDA)-type agonist. In cultured rat hippocampal neurones, L-C...

Journal: :Biochemical Society transactions 1993
R Griffiths

1,-Glutamate is now well established as the predominant transmitter at fast-acting excitatory synapses in the mammalian central nervous system. Other amino acids such as L-aspartate and several acidic sulphur-containing amino acids (SAAs) which exhibit potent depolarizing actions similar to that of Lglutamate [I-31 are known to exist in the brain and/or are present in the brain under pathologic...

Journal: :Experimental Diabetes Research 2007
Jose E. Pulido Jose S. Pulido Jay C. Erie Jorge Arroyo Kurt Bertram Miao-Jen Lu Scott A. Shippy

Diabetic retinopathy is a leading cause of vision loss. The primary clinical hallmarks are vascular changes that appear to contribute to the loss of sight. In a number of neurodegenerative disorders there is an appreciation that increased levels of excitatory amino acids are excitotoxic. The primary amino acid responsible appears to be the neurotransmitter glutamate. This review examines the na...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Shumin Duan Christopher M Anderson Edmund C Keung Yongmei Chen Yiren Chen Raymond A Swanson

Astrocyte glutamate release can modulate synaptic activity and participate in brain intercellular signaling. P2X7 receptors form large ion channels when activated by ATP or other ligands. Here we show that P2X7 receptors provide a route for excitatory amino acid release from astrocytes. Studies were performed using murine cortical astrocyte cultures. ATP produced an inward current in patch-clam...

Journal: :iranian journal of applied animal science 2015
y. dersjant-li m. peisker

amino acids (aa) are important in poultry nutrition not only for protein deposition, but also for other metabolic functions; such as improving immune and gut functions. although, some table values are available on amino acids requirement, aa requirements may vary due to changes in dietary composition and breeding selection. thus amino acids requirements have remained an ongoing research topic. ...

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