Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N',N'-dimethylaminoethyl)aspartamide...

The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrop...

The use of lipid-based dosage forms for enhancement of drug absorption or delivery has drawn considerable interest from pharmaceutical scientists. The unique characteristics of these dosage forms, however, present significant challenges to pharmaceutical industry and regulatory agencies in many ways. For example, safety assessment is necessary when the use of a new lipid excipient is considered...

Floating calcium alginate beads based on gas-generation technique often suffer from poor drug encapsulation and rapid drug release in the acidic environment of the stomach. To overcome the above mentioned demerits, in the present study we have evaluated the influence of formulation factors such as incorporation of mixtures of gasgenerating agents (NaHCO3 and CaCO3), incorporation of gelatin typ...

The stability of a moisture-sensitive drug in lyophilized products was investigated under conditions with varying water content and temperature using two model formulations: a formulation containing inositol (IF) as the excipient and a formulation containing mannitol (MF) as the excipient. IF showed better chemical stability (a lower hydrolysis rate) than MF when both formulations contained 2% ...

Excipients play an essential role in the physical and chemical characteristics of oral dosage form. The excipient modification can alter parameters like dissolution disintegration. Oral form passes through varying pH human gastrointestinal tract delivers drug at a specific site. For providing pH-responsive form, novel techniques are used, which include hydrogels, nanoparticles, microspheres. ar...

Acid-base properties of excipient surfaces have been studied by photoacoustic spectroscopy (PAS) in the visible absorption range using seven acid-base indicators. The acid strength (Ho) of each excipient was determined from the PA spectral patterns of the indicators. The Ho values of silica-alumina, silica-magnesia and crystalline cellulose were determined to be between 3.3 and -3 .0, between 4...

The oral bioavailability of many lipophilic bioactive agents (pharmaceuticals and nutraceuticals) is limited due to various physicochemical and physiological processes: poor release from food or drug matrices; low solubility in gastrointestinal fluids; metabolism or chemical transformation within the gastrointestinal tract; low epithelium cell permeability. The bioavailability of these agents c...

In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p<0.05) were obtain...

Servicio de Dermatología, Hospital General Universitario de Valencia, Spain in 2004 and 2005.6 The highest number of positive reactions was seen with ketoprofen (45 cases). Promethazine occupied sixth place with 7 cases, although in none of them were the reactions considered relevant. In our experience, of the 48 photopatch tests done in the Dermatology Department of Hospital 12 de Octubre in M...