Background: Psoriasis is an autoimmune-mediated disease characterized marked by thickened plaques and erythematous skin, which can be treated topical delivery of apremilast. The objective this study was to prepare hydrogel-based nanoemulsions apremilast for psoriasis therapy with a view improving its solubility permeability. Methods: Nanoemulsion components were chosen based on their solubility...

PURPOSE Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS In this study, for combination anesthesia and over...

Abstract: Background: The aim of this study was to enhance the solubility Natamycin, an antifungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic films with purpose avoid frequent dosing, period retention, and sustaining release for better patient compliance. Materials Methods: Firstly, dispersions were prepared by solvent evaporation method then, best formulat...

Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a gly...

A series of isopropyl fatty esters having different chain length (C(13)-C(23)) were synthesized and formulated in lipid nanoparticles based on Precirol ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by hig...

OBJECTIVE The purpose of this study was to improve skin permeation of evodiamine and rutaecarpine for transdermal delivery with microemulsion as vehicle and investigate real-time cutaneous absorption of the drugs via in vivo microdialysis. METHODS Pseudoternary phase diagrams were constructed to evaluate microemulsion regions with various surfactants and cosurfactants. Nine formulations of oi...