BetaSheet916 (Cheng and Baldi, 2005) consists of 916 protein chains with an available X-ray structure of resolution below 2.5 Å. These chains contain 31,638 β-residue contacts distributed into 4519 antiparallel β-strand contacts, 2214 parallel β-strand contacts and 1429 isolated β-bridges. BetaSheet1452 (Savojardo et al., 2013) was built from the structures deposited in the Protein Data Bank af...

Abnormal findings on neurological examination were evaluated in 165 patients with a clinical diagnosis of Alzheimer's disease who attended a memory disorders clinic. Severity of dementia was measured by the Blessed Dementia Scale, and associations of abnormalities with dementia severity were evaluated using logistic regression. Presence of aphasia, apraxia, and primitive reflexes on neurologica...

This paper, written originally for a Chinese audience, is a simple description of economic cost-benefit analysis, coupled with a discussion of its applicability to project appraisal in China. It is concerned mainly with methods of estimating shadow prices for project inputs and outputs, particularly in light of the size and non-market nature of China's economy. Most of the exposition is narrowl...

The COVID-19 pandemic has made a significant impact on citizens all around the world In order to prevent spread of virus, one most important measures is practicing hand hygiene We see nudging, technique from behavioural economics, as possible way increase without relying mandatory this field experiment, we test two nudge types that previously have been applied successfully, salience and gain fr...

There are few research studies documenting the effectiveness of Computer-Based Speech Training (CBST) systems. This paper evaluates the effectiveness of the IBM SpeechViewer CBST combined with a newly developed rate control program (The Stepping Stones Game) for improving speech production in individuals with dysarthria. Three subjects were studied using a single-subject multiple baseline desig...

Recent studies have linked the Atlantic Mdtidecadal Oscillation (AMO) and the Pacific Decadal Oscillation (PDO) with drought occurrence in the interior United States. This study evaluates the influence of AM0 and PDO phases on interannual relationships between climate and wildfire-burned area during the 20th century. Palmer's Drought Severity Index (PDSI) is strongly related to burned area at b...

The genomes of several vertebrates, including six mammals, the chicken, Xenopus and four ray-finned fishes have been sequenced or are currently being sequenced to provide a better understanding of the human genome through comparative analysis. However, this list does not include cartilaginous fishes, which are the most basal living jawed vertebrates [1]. The genomes of the current ‘popular’ car...

:he "T term• in the longitudinal stressequilibrium equation for glacier mechanics, a double y-integral of fJT xylfJx where x is a longitudinal coordinate and y is roughfy normal to the ice surface, can be evaluated within the framework of longitudinal flow-coupling theory by linking the local shear stress T at any depth to the local shear stres~ T 8 at the base, whi~h is determmed by the theory...

In a mesocosm experiment, we tested whether larval fish show an active behavioural response to hydrodynamic impacts. Exposing I to 3 week old allis shad (Alosa alosa) larvae to a pulsed wave regime, we found that already I week old larvae immediately adapt their microhabitat use and activity patterns at the onset of the wave pulses. The fish larvae in stantaneously increased their activity leve...

Peptidoglycan (PG) modifying carboxypeptidases (CPs) are important determinants of bacterial cell shape. Here, we report crystal structures of Csd4, a threedomain protein from the human gastric pathogen Helicobacter pylori. The catalytic zinc in Csd4 is coordinated by a rare H+E+Q configuration that is conserved amongst most Csd4 homologs, which form a distinct subfamily of CPs. Substitution of...