1. Interactions in the rates of consumption of acetate, propionate and butyrate in sheep liver mitochondria were examined in the presence and absence of l-malate and alpha-oxoglutarate. 2. Acetate was not consumed in absence of ancillary substrate but utilization of acetate (7.2nmol/min per mg of protein) occurred in the presence of alpha-oxoglutarate. This consumption was abolished by propiona...

Aerobic, glucose-limited chemostat of Saccharomyces cerevisiae CBS 8066 co-metabolized propionate when this compound was added to the reservoir medium. Co-metabolism of propionate led to an increase of the biomass and protein yields. Attempts to grow S. cerevisiae on propionate as a sole source of carbon and energy were not successful. Activities of propionyl-CoA synthetase in cell-free extract...

The uptake of propionate by the isolated perfused rat liver is not influenced by oleate or glucagon. However, glucagon does stimulate glucose production in the presence of 10 flwl propionate and increases the incorporation of isotope from [14C]propionate into glucose. These observations have been interpreted to indicate a sparing of the metabolism of propionate in the citric acid cycle by endog...

When soybean nodules are incubated with propionate-2-(14)C the heme moiety of leghemoglobin becomes labeled. The incorporation of propionate-2-(14)C into heme is linear with time and it appears that propionate is utilized without a lag period. The rate of incorporation of propionate-2-(14)C into heme is more rapid than the rate of incorporation of succinate-2-(14)C and citrate-1,5-(14)C, howeve...

Normal cardiac metabolism requires continuous replenishment (anaplerosis) of catalytic intermediates of the citric acid cycle. Little is known about the quantitative aspects of propionate as a substrate of in vivo anaplerosis; therefore, we measured the rate of propionate entry into the citric acid cycle in hearts of anesthetized pigs. [U-(13)C(3)]propionate (0.25 mM) was infused in a coronary ...

The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose of 25 mg testosterone propionate-19,19,19-d3. Plasma levels of testosterone propionate-19,19,19-d3, its active metabolite testosterone-19,19,19-d3, and endogenous testosterone were measured by gas chromatography-mass spectrometry. Testosterone propionate-19,19,19-d3 was gradually tra...

There is a discrepancy between in vitro cholesterol dissolving efficacy of methyl-tert-butyl ether (MTBE) and ethyl propionate and cholesterol gall stone dissolution in vivo. This study investigated whether the presence of bile changes the cholesterol dissolving capacity of MTBE and ethyl propionate. The addition of dimethylsulphoxide to MTBE or ethyl propionate was also studied to discover if ...

Lipogenesis from propionate-l-Cl4 was first reported by Feller and Feist (2) in slices of liver and adipose tissue. Favarger and Gerlach (3, 4) and Masoro and Porter (5) recently studied the incorporation of propionate-1-V into fatty acids of rat and mouse adipose tissue in viva and in vitro. The incorporation of propionate, compared with that of acetate, was quite low. Favarger and Gerlach (4)...