A common feature of many advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. In a challenging study designed to assess whether such cancers can be debilitated, we seeded hepatocellular carcinoma cells expressing the highly glycolytic phenotype into two different locations of young rats. Advanced cancers (2-3cm) developed and were treated with the alkylating agent 3...

Since 1938 mammalian succinate dehydrogenase has been thought to contain thiol groups at the active site. This hypothesis was questioned recently, because irreversible inhibition by bromopyruvate and N-ethylmaleimide appeared not to satisfy the requisite criteria for reaction at the active site. These recent observations of incomplete inactivation of succinate dehydrogenase by N-ethylmaleimide ...

background: methotrexate (mtx) is an anti-metabolite drug widely used in treatment of neoplastic disorders, rheumatoid arthritis and psoriasis. the ester derivative, ethyl pyruvate (ep) is stable in solution and should function as an antioxidant and energy precursor. this study was conducted to evaluate the protective role of ep on sperm parameters, testosterone level and malondialdehyde (mda) ...

in this study a new simple selective and sensitive spectrophotometric procedure for determination of fe(iii) is described. it is based on the formation of a colored complex between ferric iron and ethyl maltol, a strong and highly selective ligand for fe(iii). after mixing sample and reagent, and incubating at the room temperature, fe(iii)-ethyl maltol complex was extracted with different solve...

CYT-0851 was discovered using a phenotypic screen and rapidly advanced to phase 1 clinical trial where responses in solid tumor lymphoma patients have been observed. To elucidate the mechanism of action (MOA) CYT-0851, extensive bioinformatic, functional genomic, molecular characterization performed. This preclinical work demonstrated that disrupts lactate transport via inhibition monocarboxyla...

introduction bolus is a soft and resilient material which is used for increasing skin dose or to even out the irregular patient contour. the main property of various materials used presently as bolus is the water-equivalent electron density. ethyl methacrylate is used as a soft-liner in dentistry and its physical and chemical properties are proved to be nontoxic for human body. the goal of this...

the purpose of this study was to prepare and characterize nimodipine loaded microspheres using ethyl cellulose (ec) as a carrier polymer through an emulsion solvent evaporation method. these evaluations characterized the pattern of drug release from prepared microspheres. nimodipin loaded microspheres were prepared using an emulsification solvent evaporation method. the effect of process variab...