نتایج جستجو برای: esat6
تعداد نتایج: 122 فیلتر نتایج به سال:
In this study, the early pulmonary cytokine and chemokine responses in mice immunized with either BCG vaccine, a DeltasecA2 mutant of Mycobacterium tuberculosis, or a DNA vaccine expressing an ESAT6-antigen 85B fusion protein and then aerogenically challenged with a low dose of M. tuberculosis were evaluated by PCR array. The cellular immune responses at day 10 postchallenge were essentially eq...
New innovative vaccines are highly needed to combat the global threat posed by tuberculosis. Efficient components-antigens and adjuvants-are crucial for development of modern recombinant TB vaccines. This study describes a new vaccine (GamTBvac) consisting of two mycobacterial antigen fusions (Ag85A and ESAT6-CFP10)-with dextran-binding domain immobilized on dextran and mixed with an adjuvant c...
On 16 January 1924, Allen Krause gave an address entitled “The spread of tuberculous infection in the body” before the Bronx County Medical Society, under the auspices of the New York Tuberculosis (TB) Association [1]. He said “few of us, it would seem, think of the possibility of a more general distribution of infection as perhaps the mode of tuberculosis; of bacilli nesting in many places thr...
BACKGROUND To investigate the ability of rESAT6 to identify different mycobacteria-sensitized guinea pigs and its safety in preclinical and phase I clinical study. MATERIAL AND METHODS Guinea pigs were sensitized with different Mycobacteria. After sensitization, all animals were intradermally injected with rESAT6 and either PPD or PPD-B. At 24 h after the injection, the erythema of the inject...
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