Mitochondrial inheritance, the transfer of mitochondria from mother to daughter cell during cell division, is essential for daughter cell viability. The mitochore, a mitochondrial protein complex containing Mdm10p, Mdm12p, and Mmm1p, is required for mitochondrial motility leading to inheritance in budding yeast. We observe a defect in cytokinesis in mitochore mutants and another mutant (mmr1Del...

Aims. We performed a spectral fitting for set of O-type stars based on self-consistent wind solutions, which provide mass-loss rate and velocity profiles directly derived from the initial stellar parameters. The great advantage this is therefore reduction number free parameters to be tuned. Methods. Self-consistent values line-force ( k , α δ ) sc subsequently rate, M terminal velocity, υ ∞‚sc ...

BACKGROUND Mitochondrial inheritance is essential for cell division. In budding yeast, mitochondrial movement from mother to daughter requires (1) actin cables, F-actin bundles that undergo retrograde movement during elongation from buds into mother cells; (2) the mitochore, a mitochondrial protein complex implicated in linking mitochondria to actin cables; and (3) Arp2/3 complex-mediated force...

In the budding yeast, S. cerevisiae, mitochondrial distribution involves movements of the organelle from the mother cell to the bud (anterograde movement) and from the bud to the mother (retrograde movement). Both types of movements require actin cables, dynamic bundles of F-actin filaments, which undergo continuous retrograde flow from the bud into the mother and provide tracks for mitochondri...

T he ability of mitochondria to perform numerous different functions is refl ected in the organelle's complex architecture. The mitochondrial inner membrane, in particular, is organized into distinct regions that carry out specialized functions (1). Boundary regions are where the inner membrane contacts the outer membrane to facilitate protein import and respiratory complex assembly. Once assem...

This paper tests for the presence of asymmetric information in the viager real estate market. Sellers who use the viager mechanism are entitled to stay in their property until death. Buyers have to make a down payment at the purchase date, and pay regular sums of money until the seller dies. Thanks to a no arbitrage condition (buyers must be indifferent between purchasing on the standard and vi...

Conventional studies of absenteeism concentrate on labour supply aspects. In this paper we analyse records of worker behaviour which enable us to investigate whether or not demand side effects exist. Are there differences in contract structure and behaviour across firms that can help explain the observed pattern of absence rates? The theoretical background to the study is the model in Coles and...

Puf3p binds preferentially to messenger RNAs (mRNAs) for nuclear-encoded mitochondrial proteins. We find that Puf3p localizes to the cytosolic face of the mitochondrial outer membrane. Overexpression of PUF3 results in reduced mitochondrial respiratory activity and reduced levels of Pet123p, a protein encoded by a Puf3p-binding mRNA. Puf3p levels are reduced during the diauxic shift and growth ...