The aim of this study was to evaluate the immunohistochemical expression of epidermal growth factor (EGFR) and c-erb-B-2 oncoprotein in a series of 71 hepatocellular carcinomas as well as in the adjacent hepatic tissue and to assess any correlation with HBsAg expression. The total of the 71 hepatocellular carcinomas (HCCs) was classified into 17 low grade and 54 high grade cases with adjacent n...

The EGFR/Erb-B receptor tyrosine kinases each play distinct and complementary roles in normal breast development. The four receptors form both homodimers and heterodimers in response to binding by ligands which show selectivity for one or more of the receptors (except Erb-B2). Together with the additional flexibility generated by the formation of different dimer pairs, these signalling networks...

The aim of the study was to compare the localisation of oestrogen receptors a and b (ERa and ERb) in the human and rat epididymides. In the human epididymis the immunoexpression for ERa was detected in the nuclei of the caput epithelial cells, while positive reaction for ERb was observed in the nuclei of the cauda epithelial cells. In the rat epididymis, immunoexpression for ERa showed nuclei o...

Two site-specific anti-peptide antisera have been produced that efficiently recognize the native form of the v-erb B protein from avian erythroblastosis virus (AEV)-infected chicken erythroblasts and fibroblasts, and from AEV-transformed mammalian cells. Since the antibodies were generated against synthetic sequences, the immunoprecipitations could be performed in the presence or absence of imm...

The aim of the study was to evaluate the correlation of c-erb-b2 and Bcl-xl expression in biopsy specimens of Barrett's oesophagus from 44 patients with morphological features. The examined group was subdivided into: negative for dysplasia, indefinite for dysplasia, positive for dysplasia-low grade, and adenocarcinoma with high grade dysplasia. Positive c-erb-B2 staining was found in 34.1% and ...

The ACRIM-gap (1989.5-1991.75) continuity dilemma for satellite TSI observations is resolved by bridging the satellite TSI monitoring gap between ACRIM1 and ACRIM2 results with TSI derived from Krivova’s [2007] proxy model based on variations of the surface distribution of solar magnetic flux. ‘Mixed’ versions of ACRIM and PMOD TSI composites are constructed with their composites’ original valu...

Erythrosine (ErB) is a xanthene and an US Food and Drug Administration approved dye used in foods, drugs and cosmetics. Although its utilization is permitted, ErB is described as inhibitor of enzymes and protein-protein interactions and is toxic to pituitary and spermatogenesis processes. However, the genotoxicity and mutagenicity of ErB is inconclusive in the literature. This study aimed to an...

Soundscape perception (SP) plays an important role in promoting tourist-place interaction and enhancing tourists’ environmentally responsible behavior (ERB). In this study, we defined SP as a second-order factor investigated its relationships with place attachment (PA) ERB using structural equation modeling (SEM). Our aim was to identify how soundscape could be improved enhance the of forest pa...

To exploit overexpression of erbB2 in human cancers, we constructed a single-chain immunotoxin (erb-38) that contains the Fv portion of monoclonal antibody e23 fused to a truncated form of Pseudomonas exotoxin A. In a Phase I study, five breast cancer patients and one esophageal cancer patient received three doses of erb-38 at 1.0 and 2.0 microg/kg. Hepatotoxicity was observed in all patients. ...

Abstract Although studies have shown beneficial effects of the phytoestrogen genistein on reducing ovarian cancer risk, little is known at molecular level regarding how inhibits growth, with estrogen receptor beta (ERb), a hormone-regulated transcription factor, receiving bulk attention. When endogenous and exogenous ligands engage ERb, binds to regulatory regions in genome as enhancers, where ...