نتایج جستجو برای: equine antivenom

تعداد نتایج: 14573  

2003
David Williams Ben Bal

Nine cases of serious envenomation following bites by Papuan taipans Oxyuranus scutellatus canni are presented. Eight cases were fatal with contributing factors such as delayed presentation with advanced symptoms, incorrect antivenom administration, failure to recognise key indications of envenoming, lack of antivenom, and delayed administration of correct antivenom. The survival of a single pa...

2010
Nicholas R. Casewell Darren A. N. Cook Simon C. Wagstaff Abdulsalami Nasidi Nandul Durfa Wolfgang Wüster Robert A. Harrison

BACKGROUND Snakebite is a significant cause of death and disability in subsistent farming populations of sub-Saharan Africa. Antivenom is the most effective treatment of envenoming and is manufactured from IgG of venom-immunised horses/sheep but, because of complex fiscal reasons, there is a paucity of antivenom in sub-Saharan Africa. To address the plight of thousands of snakebite victims in s...

2012
George E. Allen Simon G. A. Brown Nicholas A. Buckley Margaret A. O’Leary Colin B. Page Bart J. Currie Julian White Geoffrey K. Isbister

BACKGROUND Snakebite is a global health issue and treatment with antivenom continues to be problematic. Brown snakes (genus Pseudonaja) are the most medically important group of Australian snakes and there is controversy over the dose of brown snake antivenom. We aimed to investigate the clinical and laboratory features of definite brown snake (Pseudonaja spp.) envenoming, and determine the dos...

2017
Fan-Jie Zeng Cong Chen Ming-Hua Liu

Antivenom is the most effective method currently available for the treatment of poisonous snake bite. Allergic reactions to antivenom have been reported in the past. Here we shared a case of allergic reactions to antivenom in an old male patient who was bitten twice by the same snake (probably same one) at the same biting site within a month whereas the patient did not show any allergic disorde...

Journal: :BMJ 1999
H W Fan L F Marcopito J L Cardoso F O França C M Malaque R A Ferrari R D Theakston D A Warrell

OBJECTIVE To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom. DESIGN Sequential randomised, double blind, placebo controlled trial. SETTING Public hospital in a venom research institute, São Paulo, Brazil. PARTICIPANTS 101 patients requiring antivenom treatment after being bitten by bothrops snakes. INTERVENTION Intramuscul...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 1997
R Otero V Núñez J M Gutiérrez A Robles R Estrada R G Osorio G Del-Valle R Valderrama C A Giraldo

Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atrox from Antioquia and Chocó (Colombia). The following antivenoms were used: a) polyvalent (crotaline) antivenom produced by Instituto Clodomiro Picado (Costa Rica), b) monovalent antibothropic antivenom produced ...

2013
Gregory Cham Francis Lim Arul Earnest Ponnampalam Gopalakrishnakone

Naja sumatrana is the dominant cobra species in Malaysia, Singapore, Borneo, and Sumatra, and it does not have specific antivenom. The Haffkine antivenom has been advocated instead. This study aims to determine the efficacy of this antivenom against Naja sumatrana envenoming using a mouse model. Methods. Male Swiss albino mice were used. Intravenous LD50 was first determined separately for Naja...

2018
Mo Li Zhi-Hui Xie An-Yong Yu Dong-Po He

BACKGROUND Snakebites are a neglected threat to global human health with a high morbidity rate. The present study explored the efficacy of antivenom with hyperbaric oxygen (HBO) intervention on snakebites, which could provide the experimental basis for clinical adjuvant therapy. METHODS Male Sprague-Dawley rats (n = 96) were randomized into four groups: the poison model was established by inj...

2012
Poh Kuan Leong Si Mui Sim Shin Yee Fung Khomvilai Sumana Visith Sitprija Nget Hong Tan

BACKGROUND Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy. Cross-neutralization of heterologous venoms by antivenom raised against venoms of closely related species has been reported. The present study examined the cross neutralizing potential of a newly develo...

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