Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...

determinants of early onset haze were retrospectively explored in patients who had been undergone laser-assisted sub-epithelial keratectomy (lasek) in a private eye clinic. the technique included creating an epithelial flap following 20 seconds exposure to 20% alcohol. ‘optimized’ ablation profile was used by allegretto laser (wavelight technologie). following repositioning of the flap, a singl...

Introduction: Amniotic membrane, the innermost layer of extra-embryonic tissue, contains mesenchymal and epithelial stem cells. The amniotic mesenchymal cells have the capability of inhibition of growth of cancer cells. In this research, the effects of amniotic epithelial cells on the viability of cancer cells and the role of apoptosis in this procedure were evaluated. Methods: Amniotic mem...

 Abstract Background: Transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. This study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. Methods: In a ...

Background: Formaldehyde is a chemical that used in fixed tissues and bodies. Formaldehyde during dissection of cadaver, evaporate and be released. Studies have shown that the gas increase endogenous opioids, nitric oxide and cytokines in plasma. These impacts can affect on gonadotropin hormones. The aim of this study was to investigate possible changes in gonadotropin and epithelial cells of t...

purpose: to evaluate the results of one 60-degree block conjunctival limbal autograft (clau) surgery in patients with unilateral total limbal stem cell deficiency (lscd). methods: five eyes of 5 patients were included. all patients had a history of chronic total unilateral lscd due to a chemical injury. two patients underwent one 60-degree block clau with amniotic membrane transplantation, two ...

Objective(s): Severe injuries are often associated with tissue hypothyroidism, elevated damaging mediators in circulation, and broken gut epithelial barrier.  However, the relationships between the hypothyroid state and gut epithelial damage are largely unknown.  Therefore, in this study, we investigated the effects of L-thyroxine (T4) on in vitro models of intact and ...

Epithelial-mesenchymal plasticity plays a critical role in many solid tumor types as mediator of metastatic dissemination and treatment resistance. In addition, there is also growing appreciation that the epithelial/mesenchymal status immune evasion suppression. A deeper understanding immunological features different has been facilitated by availability large gene expression datasets developmen...

abstract background: transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. this study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. methods: in a c...