The availability of zebrafish larvae model of epileptic seizure provides opportunities to identify novel anticonvulsants for treatment of people with epilepsy. However, the major parameters of zebrafish behavior assay for assessing anti-epileptic drug efficacy existed disparity, which resulted in different results in previous studies. In this study, we chose the high, medium, slow-speed moved d...

www.neurosciencesjournal.org E is a neurological disorder characterized by recurrent seizures, which result in an altered level of consciousness.1 Although appropriate management with antiepileptic drugs can result in seizure remission, 3040% of epileptic patients are incompletely controlled.1 A number of studies have shown that epileptic patients are more likely than age-matched controls to ex...

Records of brain electrical activity from intracranial EEG of four patients with different types of epilepsy are analyzed to predict the epileptic seizure onset. A method based on the evolution of the accumulated energy using wavelet analysis is introduced. This is an efficient method to predict epileptic seizures: from 13 preseizure signals, the seizure onset in 12 of those are predicted.

The iron-induced model of post-traumatic chronic focal epilepsy in rats was studied by depth-electrode mapping to investigate the spread of epileptiform activity into subcortical brain structures after its onset in the cortical epileptic focus. Electrical seizure activity was recorded in the hippocampal CA1 and CA3 areas, amygdala and caudate-putamen, in rats with iron-induced chronic cortical ...

Understanding the transition of brain activity towards an epileptic seizure, called pre-epileptic seizure, is a challenge in epilepsy. In this Letter, a recurrence quantification analysis (RQA) is proposed to describe dynamical characteristics of EEG (electroencephalograph) recordings on rat experiments, which is helpful to predict seizures. One of the advantages of this method does not require...

OBJECTIVE To explore the factors associated with preoperative epileptic seizure and surgical outcome in patients with cerebral gangliolioma (GG). METHODS A total of 31 consecutive patients with pathologically confirmed ganglioglioma and surgically treated from January 2003 to June 2011 in West China Hospital of Sichuan University were retrospectively reviewed. Clinical data, surgical procedur...