Magnetoencephalography (MEG) records the magnetic field generated by electrical activity of cortical neurons. The signal is not distorted or attenuated, and it is contactless recording that can be performed comfortably even for longer than an hour. It has excellent and decent temporal resolution, especially when it is combined with the patient's own brain magnetic resonance imaging (magnetic so...

Background Since 2003, Epilia has provided online personalized consultations for patients with epilepsy and their families. Methods More than 5,000 questions from the past 19 years were reviewed analyzed to investigate needs of epilepsy. Results Overall, families asked more themselves, especially under 20 old or in over 60 old. Patients 20s 40s, contrast, The most frequently question type throu...

Despite the new advancements in antiepileptic drug development, thousands of people with epilepsy will remain intractable to medication. For a considerable proportion of these people, epilepsy surgery is a consideration for better control of their seizures. Resective surgery is now standard practice for patients with medication-refractory epilepsy. Temporal lobectomy continues to be the most co...

PURPOSE Due to differences in epilepsy types and surgery, economic evaluations of epilepsy treatment in adults cannot be extrapolated to children. We evaluated the cost-effectiveness of epilepsy surgery compared to medical treatment in children with intractable epilepsy. METHOD Decision tree analysis was used to evaluate the cost-effectiveness of surgery relative to medical management. Fiftee...

BACKGROUND Randomized trials of surgery for epilepsy have not been conducted, because of the difficulties involved in designing and implementing feasible studies. The lack of data supporting the therapeutic usefulness of surgery precludes making strong recommendations for patients with epilepsy. We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for tempora...

PURPOSE Although epilepsy surgery, especially temporal lobe epilepsy surgery, is well established to control seizures in patients remaining on antiepileptic drug (AED) treatment, less information is available about how many seizure-free surgical patients will relapse after discontinuation of AEDs under medical supervision. METHODS A literature review yielded six retrospective clinical observa...

background: mesial temporal lobe epilepsy (tle) is a remediable epileptic syndrome. about 40% of patients continue to have seizures after standard temporal lobectomy. it has been suggested that some of these patients could actually suffer from a more complex epileptogenic network. because a few papers have been dedicated to this topic, we decided to write an article updating this theme. methods...

OBJECTIVE To investigate prospective, population-based long-term outcomes concerning seizures and antiepileptic drug (AED) treatment after resective epilepsy surgery in Sweden. METHODS Ten- and 5-year follow-ups were performed in 2005 to 2007 for 278/327 patients after resective epilepsy surgery from 1995 to 1997 and 2000 to 2002, respectively. All patients had been prospectively followed in ...

For some patients with medically refractory epilepsy (MRE), surgery is a safe and effective treatment for controlling epilepsy. However, the functional consequences of such surgery on brain activity and connectivity in children remain unknown. In the present study, we carried out a longitudinal study using resting-state functional magnetic resonance imaging in 10 children with MRE before and ag...

Epilepsy surgery is often the only effective treatment in appropriately selected patients with drug-resistant epilepsy, a disease affecting about 30% of those with epilepsy. We review the evidence supporting the use of epilepsy surgery, with a focus on randomized controlled trials (RCTs). Second, we identify gaps in knowledge about the benefits of epilepsy surgery for certain populations, the c...