نتایج جستجو برای: epigenetic modification

تعداد نتایج: 162408  

2012
Qidong Hu Michael G. Rosenfeld

Recently, there has been tremendous progress in characterizing the transcriptional network regulating human embryonic stem cells (hESCs; MacArthur etal., 2009; Loh etal., 2011), including those signaling events mediated by Oct4, Nanog, and Sox2. There is growing interest in the epigenetic machinery involved in hESC self-renewal and differentiation. In general, epigenetic regulation includes chr...

2015
Yanjun Huan Zhanfeng Wu Jiguang Zhang Jiang Zhu Zhonghua Liu Xuexiong Song Liangxue Lai

Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Epigenetic modification agents can improve genomic methylation reprogramming and the development of cloned embryos, however, the effect of epigenetic modification agents on gene-specific methylation reprogramming remains poorly studied. Here, we investigated DNA methylation reprogramming of pluripotency...

Journal: :Cell 2015
Eric Lieberman Greer Mario Andres Blanco Lei Gu Erdem Sendinc Jianzhao Liu David Aristizábal-Corrales Chih-Hung Hsu L. Aravind Chuan He Yang Shi

In mammalian cells, DNA methylation on the fifth position of cytosine (5mC) plays an important role as an epigenetic mark. However, DNA methylation was considered to be absent in C. elegans because of the lack of detectable 5mC, as well as homologs of the cytosine DNA methyltransferases. Here, using multiple approaches, we demonstrate the presence of adenine N(6)-methylation (6mA) in C. elegans...

2015
Saber Imani Yunes Panahi Jafar Salimian Junjiang Fu Mostafa Ghanei

Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. Epigenetic regulation of gene expression is a growing research topic and is ...

Journal: :Endocrine-related cancer 2012
William D Foulkes

Hypotheses are built upon data, but data require hypotheses before they can be understood. The development of the 'two-hit' hypothesis of carcinogenesis was a key event in cancer genetics because it provided a testable model of how tumours develop. In this commentary on 'Promoter hypermethylation patterns in Fallopian tube epithelium of BRCA1 and BRCA2 germline mutation carriers' by Bijron et a...

Journal: :PLoS ONE 2008
W. Jason Cummings David W. Bednarski Nancy Maizels

Homologous recombination is essential for maintaining genomic integrity. A common repair mechanism, it uses a homologous or homeologous donor as a template for repair of a damaged target gene. Such repair must be regulated, both to identify appropriate donors for repair, and to avoid excess or inappropriate recombination. We show that modifications of donor chromatin structure can promote homol...

2017
Kuei-Yang Hsiao Meng-Hsing Wu Shaw-Jenq Tsai

Background Endometriosis is one of the most common gynecological diseases that greatly compromises the quality of life in affected individuals. A growing body of evidence shows that the remodeling of retrograde endometrial tissues to the ectopic endometriotic lesions involves multiple epigenetic alterations, such as DNA methylation, histone modification, and microRNA expression. Methods This ...

Journal: :Biological Psychiatry 2015
Gabriel Oh Sun-Chong Wang Mrinal Pal Zheng Fei Chen Tarang Khare Mamoru Tochigi Catherine Ng Yeqing A. Yang Andrew Kwan Zachary A. Kaminsky Jonathan Mill Cerisse Gunasinghe Jennifer L. Tackett Irving I. Gottesman Gonneke Willemsen Eco J.C. de Geus Jacqueline M. Vink P. Eline Slagboom Naomi R. Wray Andrew C. Heath Grant W. Montgomery Gustavo Turecki Nicholas G. Martin Dorret I. Boomsma Peter McGuffin Rafal Kustra Art Petronis

BACKGROUND Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined. METHODS We performed DNA modification analysis in white blood cells from monozygotic twins discordant f...

2016
InbEsAt KhAn hEMAnt sIngh MAhAVIr YADAV

Epigenetic process are one of the most diverse & dynamic concept, which is controlled by a group various highly specialized cellular events like DNA methylation (5-methyl cytosine, 5-hydroxymethyl cytosine, 5-fluoro Cytosine, 5-carboxyl cytosine), histone modification (acetylation, methylation, phosphorylation, sumoylation, biotinylation, citrulination, ubiquitinylation, krotonilation, isomeriz...

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