نتایج جستجو برای: epigenetic barrier for cloning
تعداد نتایج: 10427260 فیلتر نتایج به سال:
Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...
asthma is a complex, heterogeneous and chronic airway inflammatory disease with different clinical phenotypes caused by diverse triggers and pathophysiological mechanisms. asthma heritability has been established in many genetic studies but it is evident that only genetic elements are not responsible for the development of asthma. increasing rate of asthma incidence during past decades has impl...
Introduction: Cloning technology has been strengthened a long human desire for eternal life. The possibility of human cloning is the new challenges in medical education and medical ethics. The present study discussed the different perspectives in this field. Methods: This study is a review article. Related books and some database such as SID, Irandoc, Elsevier, PubMed, Magiran were searched us...
The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper response to infection requires precise regulation of powerful immune homing signals such as tumor necrosis factor (TNF). Dysregulation of TNF leads to inflammatory bowel diseases (IBD), but the mechanism controlling the expression of thi...
Differentiation within multicellular organisms is controlled by epigenetic markers transmitted across cell division. The process of differentiation will modify these epigenetic markers so that information that one cell type possesses can be lost in the transition to another. Many of the systems that encode these markers also exist in unicellular organisms but do not control differentiation. Thu...
In this paper, the author aims to study orthodox and protestant points of views on human cloning and investigate on their arguments for and against it. Both ideologies have abolished both reproductive and therapeutic cloning and put forward an argument against them. The only liberal view which allows therapeutic cloning, but refrains from explicitly commenting on reproductive cloning, is a cult...
As a scientific achievement of the modern world, cloning has caused both fears and hopes for the future of the humankind. It is categorized into human and non-human cloning, each of which are subdivided into therapeutic and reproductive subtypes. Of these subtypes, only the reproductive category has produced much controversy, but there is not much debate on animal cloning. Human cloning for the...
Cancer is caused by aberrant genetic and epigenetic changes in genes expression. DNA methylation, histone modification, and microRNAs gene deregulation are the most known epigenetic changes in different stages of cancer. Since every tumor has its own specific epigenome, any abnormal pattern is a potential biomarker for classification of different types of tumors. Despite, tumorigenesis, abnorma...
background: tuberculosis (tb) remains as a major cause of death around the world. construction of a new vaccine against tuberculosis is an effective way to control it. several vaccines against this disease have been developed. the aim of the present study was to cloning of tb10.4 gene in pcdna3.1+ plasmid and evaluation of its expression in eukaryotic cells. methods: firstly, tb10.4 fragment wa...
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