background: pan-igg specific monoclonal antibodies (mabs) are essential tools for assessment of humoral immunity, immune deficiency and gammopathy. in this study, four hybridoma clones producing mabs with different specificities for human igg isotypes were established. methods: splenocytes from balb/c mice immunized with fc fractions of human igg were fused with sp2/0 myeloma cells. hybridoma c...

universal vaccination of neonates and children against diphtheria, tetanus and pertussis has had a tremendous impact on the control of these infectious diseases worldwide. immunization by the triple diphtheria, tetanus and whole cell pertussis vaccine (dtwp) has been applied in iran for almost 50 years. periodic assessment of immunogenicity of this vaccine is an important aspect of successful m...

cystic echinococcosis is an important zoonosis in the sheep rising areas of iran. to develop a simple and reliable diagnostic method for echinococcus infection in definitive hosts, e. granulosus polyoclonal antibodies (polyabs) were prepared from adult worm in rabbit. a selected poab was used for coproantigen detection in faecal samples obtained from animals naturally infected with echinococcus...

background toxoplasma gondii is an opportunistic parasitic organism causing infection in many mammals, including immunosuppressed patients. toxoplasmosis as an opportunistic infection is highly prevalent among patients receiving a kidney transplant. objectives the purpose of this study was to identify and determine the prevalence of toxoplasma gondii in clinical samples collected from patients ...

conclusions our results suggest that human exposure to mcpyv occurs throughout life. the mcpyv antibody levels remained high among older adults in our population, consistent with reports from other populations. patients and methods in this cross-sectional study, we collected 440 serum samples from healthy individuals 2 to 78 years of age who visited the pasteur institute’s clinic in tehran, ira...

background: retroviruses of human t-lymphotropic viruses (htlv-1 and htlv-2) have been demonstrated to be endemic in the north-eastern region of iran. this study aims to determine htlv-1 and htlv-2 prevalence among healthy individuals in neyshabur city during 2010-2014. methods: a total of 8054 blood samples were collected from healthy participants in neyshabur, north-eastern iran. the blood sa...

results 34 (34%) of the renal transplant recipients and 26 (26%) of the control group were positive for anti-toxoplasma igg. in addition 18 (18%) of the renal transplant recipients and 4 (4%) of the control group were positive for anti-toxoplasma igm. for both values of the antibodies, differences were statistically significant (p < 0.025 and p < 0.001 respectively). the pcr results indicated t...

conclusions the present study supported the contamination with t. gondii as a risk factor for schizophrenia just in women. results the analyses confirmed the significant differences between healthy women and ones with schizophrenia (p = 0.001) as well as between males and females with schizophrenia (p = 0.009) in igg positivity. materials and methods t. gondii igg antibodies of 100 patients wit...