cisplatin (cp) as an important anti-tumor drug causes nephrotoxicity mainly by oxidative stress and renin-angiotensin system (ras). since flavonoids have high antioxidant activity and probable role in the inhibition of ras, this study was designed to investigate the protective effect of hydroalcoholic extract and flavonoid fraction of morus alba leaves on cisplatin-induced nephrotoxicity in rat...

background: hypomagnesaemia is one of the main side effects of cisplatin-based chemotherapy regimens in cancer patients. the aim of the current investigation was to evaluate the effect of oral magnesium oxide (mgo) supplementation on cisplatin-induced hypomagnesemia. methods: this parallel-randomized controlled, open label trial was conducted in a hospital of iran university of medical sciences...

The polyphenolic constituents and antioxidant activity of aqueous and acetone extracts of Vachellia karroo leaves were determined in order to evaluate its efficacy in scavenging radicals such as DPPH, ferric reducing power and nitric oxide as an antioxidant model. The flavonols and flavonoid and phenolic content of the leaf extracts were also accessed using benchmark phytochemical reaction meth...

Dalbergia latifolia Roxb. (Family: Fabaceae) is a traditional herb, contain latinone and dalcriodain flavonoid having excellence medicinal value. Antioxidants play an important role for protecting the human body against damage by reactive free radicals. Methods: The antioxidant activities and phenolic contents of the ethanolic extract of the bark of Dalbergia latifolia was evaluated using in vi...

The present work uses X-ray photoelectron spectroscopy (XPS) analysis to compare the chemical composition of native oxide films formed spontaneously on commercial pure magnesium and AZ31, AZ80 and AZ91D magnesium alloys. The study considers both the outer surface and inner regions of the films with the assistance of argon ion bombardment. Possible relationships are established between the alloy...

The purpose of this study was to evaluate the antioxidant and anticholinesterase activities of yellow and white bitter yams from South Western Nigeria using methanolic extraction and simulated gastrointestinal digestion models. The phenolic compounds in the bitter yam varieties were evaluated by high performance liquid chromatography with a diode array detector (HPLC-DAD). The total phenolic co...

Nitric oxide (NO), an endogenous signaling molecule, is involved in various physiological processes and stress responses in plants. In the present research, Pyrodwarf pear (Pyrus communis) rootstocks were grown by nutrient solution to investigate the effects of sodium nitroprusside (SNP) application as an NO donor at 0, 0.1, 0.5, and 1 mM levels on plant stress tolerance, content of ma...

Dioxygenase, Flavonoid Biosynthesis, Flavonols, Genetic Control, Petunia hybrida Soluble enzyme preparations from flower buds of Petunia hybrida catalyzed the conversion of dihydroflavonols to flavonols. Dihydrokaempferol and dihydroquercetin were readily converted to the respective flavonols, whereas dihydromyricetin was a poor substrate. The reaction required 2-oxoglutarate, ascorbate and Fe2...

BACKGROUND Rhododendron anthopogonoides Maxim, a kind of traditional Tibetan medicine, has been used to remove body heat, body detoxification, cough, asthma, stomachic and swelling, eliminate abundant phlegm and inflammatory for a long time. In the present study, the total phenols and total flavonoid contents as well as antioxidative properties of the crude extract and solvent fractions of R. a...

The present study evaluated the flavonoid content, antioxidant as well as type II diabetes-related enzyme inhibition activities of ethanolic extract of certain raw and traditionally processed indigenous food ingredients including cereals, legumes, oil seeds, tubers, vegetables and leafy vegetables, which are commonly consumed by vulnerable groups in Kenya. The vegetables exhibited higher flavon...