Background. Mammalian erythroid cells undergo chromatin condensation and enucleation in their final stages of differentiation. We previously reported that Rac GTPases and their downstream target mDia2 are required for enucleation of in vitro cultured mouse fetal liver erythroblasts. However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation. Desig...

The enucleation of yeast cells is of interest for the production (by fusion) of special industrial yeast hybrids, possessing mixed cytoplasms (cybrids) but only one nucleus. Such cybrids could be designed to have a modified phenotype without change of ploidy. However, no methods for the enucleation of yeast cells have yet been reported. In animal cells, enucleation usually uses the cytochalasin...

A reappraisal of survival data on patients with uveal melanomas has led us to these impressions: (a) that the mortality rate before enucleation is low, estimated at 1% per year; (b) that the mortality rate rises abruptly following enucleation, reaching a peak of about 8% during the second year after enucleation; and (c) that approximately two-thirds of the fatalities could be attributed to the ...

BACKGROUND To analyze the demographics, indications, and surgical outcomes of anophthalmic surgery (enucleation and evisceration) at Jordan University Hospital during a 5-year period. METHODS We conducted a retrospective chart review of patients who had undergone evisceration or enucleation between August 2006 and June 2011. The data collected included age at time of surgery, sex, affected ey...

AIM To analyse the extent of bony orbital volume reduction after enucleation in humans. METHODS Volumetric studies on bony orbital volumes based on three dimensional reconstructions acquired from high resolution computed tomograph (CT) scans were performed in 29 patients with acquired anophthalmia and four patients before enucleation (controls). Eight patients (follow up 25-52 years) were enu...

INTRODUCTION Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a...

In all vertebrates, the cell nucleus becomes highly condensed and transcriptionally inactive during the final stages of red cell biogenesis. Enucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals. Enucleation has critical physiological and evolutionary significance in that it allows an elevation of hemoglobin levels in the blood and ...

Medulloepithelioma is a rare congenital tumor of the ciliary body and iris. The current classification and grading of medulloepithelioma shows inconsistencies and does not reflect clinical behavior. This position paper discusses the backgrounds of the current classification and intends to initiate a discussion on an alternative classification and grading scheme. © 2016 The Author(s) Published b...

to report a case of buphthalmos with neurofibromatosis (nf-1) who suffered with blindness suffered enucleation. physical examination & histopathology were performed. physical examination revealed buphthalmos & vascularized cornea with lower lid ectropion and orbital deformity. histopathologic findings shows plexiform neurofibroma in orbital tissue with scleral wall involvement. and hamartomatou...