نتایج جستجو برای: enos protein

تعداد نتایج: 1236383  

Journal: :American journal of physiology. Lung cellular and molecular physiology 2000
T A Parker T D le Cras J P Kinsella S H Abman

Endothelial nitric oxide (NO) synthase (eNOS) produces NO, which contributes to vascular reactivity in the fetal lung. Pulmonary vasoreactivity develops during late gestation in the ovine fetal lung, during the period of rapid capillary and alveolar growth. Although eNOS expression peaks near birth in the fetal rat, lung capillary and distal air space development occur much later than in the fe...

Journal: :Journal of the American Society of Nephrology : JASN 2000
M M Arriero J A Rodríguez-Feo A Celdrán L Sánchez de Miguel F González-Fernández J Fortes A Reyero O Frieyro J C de la Pinta A Franco C Pastor S Casado A López-Farré

Changes in the expression of endothelial nitric oxide synthase (eNOS) in the peritoneum could be involved in the peritoneal dysfunction associated with peritoneal inflammation. Demonstrated recently in bovine endothelial cells was the existence of cytosolic proteins that bind to the 3'-untranslated region (3'-UTR) of eNOS mRNA and could be implicated in eNOS mRNA stabilization. The present work...

Journal: :Circulation 2009
Cleide Gonçalves da Silva Anke Specht Barbara Wegiel Christiane Ferran Elzbieta Kaczmarek

BACKGROUND Decreased endothelial nitric oxide (NO) synthase (eNOS) activity and NO production are critical contributors to the endothelial dysfunction and vascular complications observed in many diseases, including diabetes mellitus. Extracellular nucleotides activate eNOS and increase NO generation; however, the mechanism of this observation is not fully clarified. METHODS AND RESULTS To elu...

Journal: :The Journal of biological chemistry 2001
J Igarashi S G Bernier T Michel

Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that elicits numerous biological responses in endothelial cells mediated by a family of G protein-coupled EDG receptors. Stimulation of EDG receptors by S1P has been shown to activate the endothelial isoform of nitric-oxide synthase (eNOS) in heterologous expression systems (Igarashi, J., and Michel, T. (2000) J. Biol. Chem. 275, ...

2017
Yuanzhuo Chen Bojie Jiang Yugang Zhuang Hu Peng Weiguo Chen

Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. Previous studies showed that bovine eNOS serine 1179 (Serine 1177 for human eNOS) phosphorylation enhanced NO synthesis. Meanwhile, heat shock protein 90 (Hsp90) plays a critical role in maintenance of eNOS structure and function. However, the regulatory differe...

Journal: :The Journal of biological chemistry 2011
Archana Gangopahyay Max Oran Eileen M Bauer Jeffrey W Wertz Suzy A Comhair Serpil C Erzurum Philip M Bauer

Activation of bone morphogenetic protein (BMP) receptor II (BMPRII) promotes pulmonary artery endothelial cell (PAEC) survival, proliferation, and migration. Mutations to BMPRII are associated with the development of pulmonary arterial hypertension (PAH). Endothelial dysfunction, including decreased endothelial nitric-oxide synthase (eNOS) activity and loss of bioactive nitric oxide (NO), plays...

2014
VuQuynhAnh Le Yang-Hoon Kim Jiho Min

OBJECTIVES Cigarette smoking had been recorded as the main cause of impaired endothelium- dependent vasodilation in smokers by reducing nitric oxide (NO), a production of endothelial nitric oxide synthase (eNOS). However, the mechanism of NO impairment via eNOS activity is unclear until now. In this study, cell passage is suggested to be a relevant factor to eNOS expression under cigarette smok...

Journal: :Free Radical Biology and Medicine 2023

Our previous studies revealed that echinocystic acid (EA) showed obvious attenuation of atherosclerosis in rabbits fed a high-fat diet. However, the underlying mechanisms remain to be elucidated. Considering importance endothelial progenitor cells (EPCs) atherosclerosis, we hypothesise EPCs may one targets for anti-atherosclerotic potential EA.After vitro cultivation, were exposed 100 μg/mL oxi...

Journal: :Tropical Journal of Pharmaceutical Research 2022

Purpose: To investigate the clinical effects of dexmedetomidine and propofol on erythrocyte deformability (ED) in patients undergoing laparoscopic cholecystectomy.Methods: A total 522 gallbladder removal surgery were randomly divided into groups (dexmedetomidine group), B (propofol C (control). Erythrocyte suspensions prepared from each group. Then, index (EI) was measured terms RBC deformabili...

Journal: :The Journal of biological chemistry 2002
Ruqin Kou Daniel Greif Thomas Michel

The endothelial isoform of nitric-oxide synthase (eNOS) is a key determinant of vascular tone. eNOS, a Ca(2+)/camodulin-dependent enzyme, is also regulated by a variety of agonist-activated protein kinases, but the role and regulation of the protein phosphatase pathways involved in eNOS dephosphorylation are much less well understood. Treatment of endothelial cells with vascular endothelial gro...

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