نتایج جستجو برای: engerix b
تعداد نتایج: 899347 فیلتر نتایج به سال:
low Engerix-B dose were risk factors for an impaired antibody response by univariate analysis, confi rming similar fi ndings in previous studies. Vaccine dose was the only independent predictive factor for impaired antibody response by multivariate analysis. The 20g dose proved to be inadequate. The most impressive fi nding is that although the 80g dose did not lead to an increased antibody res...
Certain short peptides do not occur in humans and are rare or non-existent in the universal proteome. Antigens that contain rare amino acid sequences are in general highly immunogenic and may activate different arms of the immune system. We first generated a list of rare, semi-common, and common 5-mer peptides using bioinformatics tools to analyze the UniProtKB database. Experimental observatio...
Objective: Patients with diabetes mellitus are at increased risk for hepatitis B virus (HBV) infection and its complications. HBV vaccination is recommended for adults with diabetes in the United States and other countries. However, few studies have assessed safety and immunogenicity of hepatitis B vaccine in such patients. We assessed the safety and immunogenicity of recombinant hepatitis B va...
Following earlier studies on high-level intracellular production of hepatitis B surface antigen (HBsAg) using recombinant Pichia pastoris, we present here in detail an enhanced method for the purification of recombinant HBsAg virus-like particles (VLPs). We have screened various detergents for their ability to promote the solubilization of recombinant intracellular HBsAg. In addition, we have a...
OBJECTIVE To evaluate the immunogenicity and safety of a novel hepatitis B vaccine, after increasing antigen concentration to 25 mug, in comparison to the reference vaccine. METHODS Single-blinded randomized trial comparing VrHB-IB (Instituto Butantan) and the reference vaccine (Engerix B(R), Glaxo Smith Kline). Volunteers aged 31 to 40 years were randomized to either experimental (n=216) or ...
OBJECTIVE Patients with end-stage renal failure are at high risk of hepatitis B virus (HB V) infection. They have impaired immune response to HBV intramuscular (i.m.) vaccine. Non-response (anti HBs titer < 100mIU/ml) hemodialysis patients (HD) with the previous three-dose i.m. vaccination were examined with booster dose vaccine by i.m. , intradermal (i.d) and subcutaneous (s.c.) routes. MATE...
The immunogenicity of three currently used hepatitis B vaccines was compared in an unselected study population in an every day travel clinical setting. Five hundred and eighteen vaccinees received Engerix-B (EB), 990 received Twinrix (TWX), and 366 were immunised with Gen-HB-Vax (GHB). Overall, 88.6% of the vaccinees, tested within the first 6 months after completion of the vaccination series, ...
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