The goal of the present study was to evaluate the role of endoglin, a transforming growth factor-beta1 (TGF-beta1) accessory receptor, in the pathogenesis of renal fibrosis. This was achieved by testing a model of tubulo-interstitial fibrosis induced by unilateral ureteral obstruction in endoglin heterozygous (Eng(+/-)) mice. Northern and Western blot analysis revealed that endoglin expression ...

BACKGROUND AND PURPOSE Bone marrow-derived cells (BMDCs) home to vascular endothelial growth factor (VEGF)-induced brain angiogenic foci, and VEGF induces cerebrovascular dysplasia in adult endoglin heterozygous (Eng(+/-)) mice. We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation. METHODS BM transplantation was performed using adult wi...

Chicken Engrailed 2 homeoprotein is transported between cells in culture. This intercellular transfer is based on unconventional secretion and internalisation mechanisms: Engrailed 2 has access to vesicles but lacks a signal sequence for secretion and is internalised by a non-endocytic process. We show that phosphorylation of a serine-rich domain within Engrailed 2 by the protein kinase CK2 spe...

OBJECTIVE Hereditary hemorrhagic telangiectasia is a genetic disorder characterized by visceral and mucocutaneous arteriovenous malformations (AVMs). Clinically indistinguishable hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 are caused by mutations in ENG and ALK1, respectively. In this study, we have compared the development of visceral and mucocutaneous A...

Endoglin (ENG) is a causative gene of type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have a higher prevalence of brain arteriovenous malformation (AVM) than the general population and patients with other HHT subtypes. The pathogenesis of brain AVM in HHT1 patients is currently unknown and no specific medical therapy is available to treat patients. Proper animal models are cr...

Full Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2007–... Director GERAD research center, Montréal, 05/2015–... Associate Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2001–05/2007 Assistant Professor Math. & Indus. Eng., École Polytechnique de Montréal, 12/2000–06/2001 Researcher Math. & Indus. Eng., École Polytechnique de Montréal, 08/1999–11/2000 A...

Full Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2007–... Director GERAD research center, Montréal, 05/2015–... Associate Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2001–05/2007 Assistant Professor Math. & Indus. Eng., École Polytechnique de Montréal, 12/2000–06/2001 Researcher Math. & Indus. Eng., École Polytechnique de Montréal, 08/1999–11/2000 A...

Hereditary hemorrhagic telangiectasia (HHT) is a vascular disease characterized by multiple focal telangiectases and arteriovenous malformations (AVMs) in the pulmonary, hepatic, and cerebral microcirculations. These fragile structures are low-pressure conduits that can affect local tissue blood flow, and their potential rupture in vital organs can lead to internal hemorrhage, anemia, and death...

Hereditary haemorrhagic telangiectasia (HHT), or Rendu-Osler-Weber syndrome, is an autosomal dominant vascular disease. The clinical manifestations are epistaxis, mucocutaneous and gastrointestinal telangiectases, and arteriovenous malformations. There are two predominant types of HHT caused by mutations in Endoglin (ENG) and activin receptor-like kinase 1 (ALK1) (ACVRL1) genes, HHT1 and HHT2, ...

Full Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2007–... Associate Professor Math. & Indus. Eng., École Polytechnique de Montréal, 06/2001–05/2007 Assistant Professor Math. & Indus. Eng., École Polytechnique de Montréal, 12/2000–06/2001 Researcher Math. & Indus. Eng., École Polytechnique de Montréal, 08/1999–11/2000 Assistant Professor Operations and Decision Systems, Un...