نتایج جستجو برای: endothelin

تعداد نتایج: 12318  

2012
Qiaoling Zhou Kanghan Liu Hongyu Wu Lihe Chen Veeraragoo Pouranan Mingxia Yuan Zhou Xiao Weisheng Peng Ao Xiang Rong Tang Wenzheng Zhang

The molecular mechanism linking aldosterone and endothelin-1 in the development of diabetic nephropathy has not been completely elucidated. Here, we provide evidence showing that streptozotocin-induced diabetic rats have significantly increased aldosterone and endothelin-1 in the kidney tissue and markedly decreased expression of Dot1a and Af9. Blocking aldosterone with spironolactone significa...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2014
Markus P Schneider Johannes F Mann

Endothelin is tightly involved in the regulation of vascular and renal function in health and in disease. In a variety of animal models of kidney disease, endothelin promotes renal injury through effects on inflammation and fibrosis. Furthermore, experimental data strongly suggest that blocking the actions of endothelin should be beneficial in patients with chronic kidney disease. However, desp...

Journal: :Pharmacology 1991
M C Yang M S Tu C K Chou C Y Hong J S Kuo

Endothelin, a potent vasoconstricting peptide, induced maximal contraction of the rat tail artery within 3 min of administration. Endothelin also caused a dose-dependent decrease in tissue levels of cAMP. Concentrations of cAMP decreased about 60% 1 min after endothelin (10(-8) M) administration, but returned to basal levels in 5 min. By contrast, tissue levels of cGMP were not changed by endot...

Journal: :Hypertension 1992
C L Guimarães J B Calixto G A Rae

In rings of rat portal vein, endothelin-1, endothelin-2, and endothelin-3 caused graded slow contractions and potentiated spontaneous contractions. The apparent EC50 values and maximal responses to 30 nM endothelin were 1.4 nM and 0.96 g for endothelin-1, 5.2 nM and 0.65 g for endothelin-2, and 1.7 nM and 0.62 g for endothelin-3 (n = 4-12). At concentrations producing half the contraction trigg...

Journal: :The Journal of thoracic and cardiovascular surgery 2003
Sohrab Fratz Ralf Geiger Hans Kresse Gabriele Roemer Michael Hennig Walter Sebening John Hess

OBJECTIVE Endothelin-1 concentrations are increased in patients with increased mean pulmonary arterial pressure, pulmonary blood flow, and pulmonary vascular resistance. However, endothelin-1 concentrations have not been well characterized in patients with congenital heart disease and normal pulmonary vascular resistance. In particular, it is unclear whether pressure or flow is the key regulato...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Sohrab Fratz Barbara Meyrick Boaz Ovadia Michael J Johengen Olaf Reinhartz Anthony Azakie Greg Ross Robert Fitzgerald Peter Oishi John Hess Stephen M Black Jeffrey R Fineman

Endothelin receptor blockade is an emerging therapy for pulmonary hypertension. However, hemodynamic and structural effects and potential changes in endogenous nitric oxide (NO)-cGMP and endothelin-1 signaling of chronic endothelin A receptor blockade in pulmonary hypertension secondary to congenital heart disease are unknown. Therefore, the objectives of this study were to determine hemodynami...

Journal: :The European respiratory journal 2011
M L Handoko F S de Man A Vonk-Noordegraaf

S ince its discovery in 1988 [1], the role of endothelin in cardiovascular disease has been intensively studied. Activation of the endothelin system is considered part of the neurohormonal response in congestive heart failure. Endothelin is produced by vascular endothelial cells and has potent vasoconstrictor effects [2]. Elevated endothelin levels induce adverse cardiac remodelling and cause p...

Journal: :Mechanisms of Development 1998
V Nataf A Amemiya M Yanagisawa N. M Le Douarin

We investigated the expression pattern of the endothelin 3 gene, of which the mutation, as well as mutation of its receptor (endothelin-B receptor), affects the development of two neural crest derivatives: enteric nervous system and melanocytes. After previous work showing that these neural crest derived cells express endothelin-B receptor or its subtype endothelin-B2 receptor in the avian embr...

Journal: :Mechanisms of Development 1998
V Nataf A Grapin-Botton D Champeval A Amemiya M Yanagisawa N. M Le Douarin

We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. Later on, while the neural crest-derived tissues of the head continue to express...

2017
James A Angus Richard J A Hughes Christine E Wright

Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertension (PAH). We hypothesized that ETB receptor-mediated clearance of endothelin-1 at specific vascular sites may compromise this targeted therapy. Concentration-response curves (CRC) to endothelin-1 or the ETB agonist sarafotoxin S6c were constructed, with endothelin receptor antagonists, in variou...

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