The pancreas contains exocrine, endocrine, and ductal cells and serves two major functions: (a) the production of digestive enzymes, such as amylase and lipase, which are secreted by exocrine acinar cells and routed to the intestine by a branched ductal network; and (b) the regulation of blood sugar, which is achieved by endocrine cells of the islets of Langerhans. The endocrine cells, arranged...

The characterization of a local renin-angiotensin system in the pancreas has attracted much attention because of its potential clinical applications. A pancreatic renin-angiotensin system may be present in humans and may interact with islet cells. Nevertheless, our knowledge of the renin-angiotensin system in the human pancreas is still in its infancy, especially in the field of endocrine oncol...

The pancreas is composed of both exocrine glands and intermingled endocrine cells to execute its diverse functions, including enzyme production for digestion of nutrients and hormone secretion for regulation of blood glucose levels. To define the molecular constituents with elevated expression in the human pancreas, we employed a genome-wide RNA sequencing analysis of the human transcriptome to...

Recent studies have implicated the signaling factor Sonic hedgehog (Shh) as a negative regulator of pancreatic development, but as a positive regulator of pancreas function in amniotes [1-4]. Here, using genetic analysis, we show that specification of the pancreas in the teleost embryo requires the activity of Hh proteins. Zebrafish embryos compromised in Hh signaling exhibit disruption in the ...

Histological and histochemical studies on the pancreas of goose (Anser albifrons) were carried out using special staining and light microscope. The pancreas in goose is serous tubuloacinar gland having exocrine and endocrine part. Smooth muscle fibres were absent in capsule of pancreas. Acinar cells have bizonal shape. Intralobular ducts, Interlobular and main excretory ducts were present withi...