introduction: the aim of this study was to evaluate the cytotoxicity of a new nano zinc-oxide eugenol (nzoe) sealer in comparison with ah-26 and pulpdent root canal sealers. methods and materials: the l929 mouse fibroblast cells were cultivated and incubated for 24, 48 or 72 h with different dilutions (1/1, 1/2, 1/4, 1/8, 1/16 and 1/32) of culture media previously exposed to either of the test ...

Voltage-activated ion channels respond to changes in membrane voltage by coupling the movement of charges to channel opening. A K+ channel-specific radioligand was designed and used to determine the origin of these gating charges in the Shaker K+ channel. Opening of a Shaker K+ channel is associated with a displacement of 13.6 electron charge units. Gating charge contributions were determined f...

The inhaled corticosteroid fluticasone furoate (FF) and the long-acting β₂ agonist vilanterol (VI) are in development as a combined once-daily therapy for asthma and chronic obstructive pulmonary disease. Our study objectives were to compare the efficacy and safety of once-daily FF/VI with FF alone and twice-daily fluticasone propionate (FP) in patients aged ≥12 years with moderate-to-severe pe...

Objective. To compare pharmacokinetics and -dynamics (PD) of insulin glargine (GLA) and detemir (DET), 24 subjects with T1DM (38±10 years, BMI 22.4±1.6, kg/m, HbA1c 7.2±0.7%, mean±SD) were studied after 2 week treatment with either GLA or DET once daily (randomized, double-blind, cross-over study). Methods. Plasma glucose (PG) was clamped at 100 mg/dl for 24-h after s.c. injection of 0.35 U/kg....

Methods Fifty ICU patients (pts.) with sepsis were enrolled in this study. All pts. were subjected to APACHE II score as a clinical scoring system on admission and every 24 h during the ICU stay. All pts. were also investigated for the serum levels of both H-FABP and Troponin I during the first 24 h after admission. Using modified Simpson ́s method, echocardiographic left ventricular (LV) end-di...

Background:Infantile colic is one of the most common causes for referral to pediatric clinics. Despite different treatments, physicians and parents are still facing difficulties in handling some cases of the disease. In this report, a different treatment is introduced for infantile colic control using Iranian Traditional Medicine. Case Presentation: A two...

What is the moving part that switches an ion channel's current on and off? In this issue of Neuron del Camino and Yellen (2001) exploit scanning cysteine mutagenesis and sulfhydryl reagents to show that the intracellular end of the S6 helices forms a mechanical gate for the Shaker potassium channel.