The present study deals with the preparation and characterization of chitosan microparticles as a drug delivery system for daunorubicin. The microparticles are prepared by the suspension method and their properties are improved by covalent crosslinking using glutaraldehyde. The obtained spherical microparticles with size of 300 μm are loaded with daunorubicin. The мorphology and chemical compos...

Kafirin microparticles have potential as colon-targeted delivery systems because of their ability to protect encapsulated material from digestive processes of the upper gastrointestinal tract (GIT). The aim was to optimize prednisolone loading into kafirin microparticles, and investigate their potential as an oral delivery system. Response surface methodology (RSM) was used to predict the optim...

Purpose: Chitosan has a high potential for transferring DNA molecules into mammalian cells because of its cationic properties. In the present study, we have investigated DNA encapsulation efficiency and loading capacity of chitosan microparticles prepared in different conditions, as well as in vitro DNA release from microparticles, and transfection of different cell lines with chitosan-DNA micr...

Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections expected to surge. When dealing with respiratory system, inefficient antibiotics heighten chance death from infection. However, alternatives are limited. Bacteriophages a valid option since they can target specific type bacterium. highly avoid any side effects when delivered. their poor st...

The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local drug delivery, due to the lung's favourable properties of a large surface area and high permeability. Pulmonary drug delivery possesses many advantages, including non-invasive route of administration, low metabolic activity, control environment for systemic absorption and avoids first bypass metabolism. H...

Copper nano/microparticles were synthesized in octadecene at 290 °C by thermal decomposition method. acetate monohydrate, stearic acid, and 1-octadecanol used as copper precursor, capping mild reducing agents, respectively, the synthesis. Borosilicate glass substrates submerged into reaction solution during synthesis coated nano/ microparticles. Thermal coating techniques combined this study. t...

Microparticles made from degradable polyhydroxyalkanoates of different chemical compositions a homopolymer of 3-hydroxybutyric acid, copolymers of 3-hydroxybutyric and 4-hydroxybutyric acids (P3HB/4HB), 3-hydroxybutyric and 3-hydroxyvaleric acids (P3HB/3HV), 3-hydroxybutyric and 3-hydroxyhexanoic acids (P3HB/3HHx) were prepared using the solvent evaporation technique, from double emulsions. The...