BACKGROUND Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal delivery of exendin-4. METHODS AND RESULTS Nanoparticles were prepared using a modified water-oil...

Chitosan is a natural polymer that can be used as source of materials because it has good characteristics. in the cosmetic sector humectant, thickener, moisturizer, antioxidant, sunscreen cream, and stabilizer. The shell chitosan shells an emulsion stabilizer Hand Body Cream product problems its unstable nature so oil water are easily separated. parameters observed were stability, pH, TPC. resu...

Complexes obtained from the electrostatic interactions between chitosan, a cationic polysaccharide, and sodium decylsulfonate, an anionic surfactant, were characterized by their conductimetric and surface-active properties. Such surfactant/polyelectrolyte complexes (SPECs) present very interesting surface-active properties, even at very low surfactant concentrations (much lower than the critica...

Chitooligosaccharides with degree of polymerization from 5 to 15 have been modified different lipophilic chains, fatty epoxide acids. Their interfacial properties such as critical micellar concentrations, rheology and tension were studied establish structure-properties relationships. ability self-assemble well their shape assessed by light scattering (dynamic static) transmission electron micro...

Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of α-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, α-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique...

This study aimed to prepare nanoemulsions coated with alginate/chitosan for oral insulin delivery. Uncoated nanoemulsions were prepared by homogenization of a water in oil in water (w/o/w) multiple emulsion that was composed of Labrafac(®) CC, phospholipid, Span™ 80 and Cremorphor(®) EL. Coating of the nanoemulsions was achieved based on polyelectrolyte cross-linking, with sequential addition o...

Microencapsulation as one of the most modern methods has remarkable effects on probiotic survival. In this study Lactobacillus casei (ATCC 39392) and Bifidobacterium bifidum (ATCC 29521) were encapsulated using calcium alginate-gelatinized starch, chitosan coating and inulin via emulsion technique, and were incubated in simulated gastric juice (along with pepsin, pH=1.5) and simulated intestina...

Microencapsulation as one of the most modern methods has remarkable effects on probiotic survival. In this study Lactobacillus casei (ATCC 39392) and Bifidobacterium bifidum (ATCC 29521) were encapsulated using calcium alginate-gelatinized starch, chitosan coating and inulin via emulsion technique, and were incubated in simulated gastric juice (along with pepsin, pH=1.5) and simulated intestina...

the effects of chitosan/biopolymer (c/p) and nanohydroxyapatite/ biopolymer (nha/p) weight ratios on particle size and its uniformity, cross-linking density and nh2 content of nano-hydroxyapatite/chitosan/gelatin (nha/c/g) microspheres were investigated. microspheres were fabricated using water-in-oil emulsion. cross-linking of microspheres was performed using water soluble carbodiimide. partic...

Theranostic nanoparticles hold great promise for simultaneous diagnosis of diseases, targeted drug delivery with minimal toxicity, and monitoring of therapeutic efficacy. However, one of the current challenges in developing theranostic nanoparticles is enhancing the tumor-specific targeting of both imaging probes and anticancer agents. Herein, we report the development of tumor-homing echogenic...