portant component of the mitochondrial respiratory chain (1). Because of its poor aqueous solubility, Coenzyme Q10 (CoQ10) presents a challenge when developing a formulation for oral administration. Many approaches have been used to improve the in vitro dissolution of CoQ10. Some of the approaches include complexation with cyclodextrins (2), preparation of redispersible dry emulsion (3), solid ...

The interest in the low energy self-emulsification techniques has exploded recent years, driven by three main trends: transition to "greener" technologies both its aspects - less consumption and replacement of petrochemicals natural ingredients; costly maintenance demanding equipment for nanoemulsification; quest efficient robust self-emulsifying formulations oral drug delivery. Here we first p...

Introduction Oral drug delivery is a $35 billion dollar industry [1] and the most preferred way of drug administration. However, the oral route is not possible for 50% of currently marketed drug compounds due to their low solubility in water. Forty percent of prospective drugs coming out of discovery pipelines are lipophilic compounds, which leads to difficulty in achieving acceptable oral bioa...

More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...

Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and...

The nano drug delivery system has emerged as a novel therapeutic approach for improved efficacy of the existing molecules. Polymeric nanoparticles, lipid based nanoparticles such solid (SLNs), nanostructured carriers, conjugates, ethosomes, liposomes, and self-emulsifying systems are few carriers used delivery. Among SLNs promising in terms biocompatible carrier enhancing bioavailability, contr...