Background: Bilateral synchronous testis germ cell tumors with different histopathology are not common. Case Presentation: Here, a case of 27-year-old male who is reported presented with bilateral testicular swellings. There was a high α-fetoprotein level with bilateral lesions on scrotal USG. Bilateral orchiectomy was performed. According to pathology report, there was a right testicular semi...

Testicular tumors are both increasing in frequency and disproportionately occur in young men; furthermore, different forms of neoplasm require different treatments. These considerations make the accurate diagnosis of testicular tumors especially important. Many of the critical distinctions involve the differentiation of seminoma from one or more potential mimics because seminoma is not only the...

We have been investigating the pathogenesis of teratocarcinomas, particularly the development of the adult, apparently benign, differentiated struc tures common to them. Although nothing is known concerning the mechanism of the changes involved, we have demonstrated that the differen tiated tissues of a teratocarcinoma are derived from embryonic cell types found within the tumor (12). These emb...

“Burned out” testicular germ cell tumors are rare, representing involuted primary tumors typically discovered during workup for metastatic disease with associated elevated serum tumor markers. Histologically, a hyalinized scar is seen, often with surrounding intratubular germ cell neoplasia. We report a 24 year-old man who presented with a two-month history of cough, dyspnea, and intermittent t...

Testicular germ cell tumors of adolescents and adults (TGCTs; the so-called type II variant) are the most frequent malignancies found in Caucasian males between 20 and 40 years of age. The incidence has increased over the last decades. TGCTs are divided into seminomas and nonseminomas, the latter consisting of the subgroups embryonal carcinoma, yolk-sac tumor, teratoma, and choriocarcinoma. The...

Embryonal carcinoma cell lines produced tumors in highly specific and unusual sites when injected into mice. The pattern that developed when cells were injected into the left ventricle of the heart involved target organs related either to specific nerve patterns or neuronal outgrowth factors, or to pathways of primordial germ cell migration. Major sites included the ovary, testis, adrenal, iris...

Embryonal carcinoma cell lines produced tumors in highly specific and unusual sites when injected into mice. The pattern that developed when cells were injected into the left ventricle of the heart involved target organs related either to specific nerve patterns or neuronal outgrowth factors, or to pathways of primordial germ cell migration. Major sites included the ovary, testis, adrenal, iris...

Glutamate behaves as the principal excitatory neurotransmitter in the vertebrate central nervous system and recently demonstrates intercellular signaling activities in periphery cancer cells. How the glutamatergic transmission is organized and operated in cancer stem cells remains undefined. We have identified a glutamatergic transmission circuit in embryonal carcinoma stem cells. The circuit i...

We have isolated, by differential library screening, eight cDNAs representing genes that are specifically expressed in the embryonal stem cell line IMT-11, when compared to the parietal endoderm-like cell line PYS-2 or to NIH3T3 fibroblasts. One of these genes, embryonal stem cell gene 1 (esg-1), was analyzed in detail. esg-1 mRNA is found at high levels in both IMT-11 and F9 embryonal carcinom...

Normal mesenchymal cells, normal epithelial cells and many transformed epithelial cells require serum attachment factors and extracellular matrix proteins for growth and differentiation in vitro, and recent evidence strongly supports a role for extracellular matrix molecules in the regulation of cell movement in vivo during early embryogenesis. We previously described the isolation and characte...