Number of potential drugs are underutilized due to a lack availability teratological data. Isosorbide Dinitrate is saviour drug in angina prophylaxis while chlorzoxazone skeletal muscle relaxant and there no adequate teratogenic study performed till date. This aims assess the effect these on vital organs using chick embryo model. White Leghorn’s (Gallus gallus domesticus) fertilised chicken egg...

The stability of citrate-capped silver nanoparticles (AgNPs) and the embryonic developmental toxicity were evaluated in the fish test water. Serious aggregation of AgNPs was observed in undiluted fish water (DM-100) in which high concentration of ionic salts exist. However, AgNPs were found to be stable for 7 days in DM-10, prepared by diluting the original fish water (DM-100) with deionized wa...

Bitterleaf or African Leaf is a herbal plant empirically used to relieve fever and kidney disease. Pharmacological research reports that the leaves have antibacterial, anti-inflammatory, antidiabetic properties, toxicity test was also conducted ensure their safety. Therefore, this experiment aimed obtain LC50 of (Gymnanthemum amygdalina Del.) ethanol water extract with ZFET (Zebra Fish Embryo A...

As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs embryo development by down-regulating Dvr1/GDF1 expression in zebrafish. Here, we investigated whether folic acid could protect against arsenic-mediated embryo toxicity. We found that folic acid supplementation increases hatching and survival rates...

OBJECTIVE This study aimed to investigate the effects of royal jelly (RJ) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (OXM). MATERIALS AND METHODS In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute (NMRI) mice (7-9 weeks of age) with a ratio of 1:3 for fertili- zation purposes were randomly divided...

Toads of the Family Bufonidae possess neurotoxins (bufadienolides) which are generally considered to be synthesized de novo. Thus, invasive toad species pose a threat native predators via toxic effects. However, influence diet on toxicity is poorly understood. We evaluated effect embryos Bufo japonicus formosus in Japan, using tadpoles (Rana pirica) as bioassay. Specifically, we compared spawne...

After its standardisation at the national level in Germany (DIN 38415-6, 2001, 2001), the 48 h sewage testing assay with zebrafish (Danio rerio) embryos has been submitted for standardisation to ISO. As an alternative to the conventional acute (96 h) fish test, a modified fish embryo test will be submitted to the OECD for chemical testing in late 2005. For this, a protocol originally designed f...

alpha-Solanine and alpha-chaconine are two naturally occurring steroidal glycoalkaloids in potatoes (Solanum tuberosum), and solanidine-N-oxide is a corresponding steroidal aglycone. The objective of this research was to screen potential cyto-toxicity of these potato glycoalkaloids using bovine oocyte maturation, in vitro fertilization techniques and subsequent embryonic development as the in v...

Biological molecules and intracellular structures operate at the nanoscale; therefore, development of nanomedicines shows great promise for the treatment of disease by using targeted drug delivery and gene therapies. PAMAM dendrimers, which are highly branched polymers with low polydispersity and high functionality, provide an ideal architecture for construction of effective drug carriers, gene...