Ellagic acid (EA) is known as a naturally occurring dietary antimutagen and anticarcinogen with strong antioxidant and anti-inflammatory activities. An SPE RP HPLC method was optimized and applied for identification and determination of ellagic acid in hips of fourteen species of roses, wildly growing in Poland. A large amount of total EA, ranged from 487.2 to 1065.2 microg/g of dry material wa...

The formulation of a novel delivery system for ellagic acid formulated via layer-by-layer (Lb-L) electrostatic deposition of biopolymers onto soybean lecithin liposomes was achieved. Optimization of parameters affecting the formulation of biopolymer-coated liposomes was carried out by monitoring changes on its size, surface charge and morphology. Ellagic acid was loaded into the liposome core a...

The present paper deals with the structure, occurrence and biological activity of ellagitannins. Ellagitannins belong to the class of hydrolysable tannins, they are esters of hexahydroxydiphenoic acid and monosaccharide (most commonly glucose). Ellagitannins are slowly hydrolysed in the digestive tract, releasing the ellagic acid molecule. Their chemical structure determines physical and chemic...

The bark of Terminalia arjuna is known for its heart-health benefits in ayurvedic literature. This has been further supported by in vivo studies on animal and human volunteers. But there is no detailed study on identification of the active ingredients such as polyphenols. Polyphenols possesses antioxidant properties and are well-known health actives, it is important to characterise polyphenols ...

Ellagic acid has been shown to have chemopreventive effects in various experimental cancer models. We wanted to see whether pure ellagic acid and natural ellagitannins from cloudberry (Rubus chamaemorus) seed and pulp have any effect on adenoma formation in Apc-mutated Min mice. From the age of 5 wk, the mice were fed either a control diet, a diet containing pure ellagic acid at 1,564 mg/kg, or...

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology, but it is now clear that pro-inflammatory cytokines play a central role in its pathogenesis. Ellagic acid (EA) has a variety of biological activities including anti-oxidant, anti-inflammatory, and anti-cancer properties. The aim of the present study was to evaluate the potential effect of ellagic acid on the preve...

The aim of the present study was to investigate the effect of ellagic acid on haloperidol-induced orofacial dyskinesia and catalepsy in Wistar male albino rats and to explore the possible underlying mechanisms for these effects. Haloperidol (1 mg/kg, ip) was administered on 21 successive days to induce orofacial dyskinesia in rats. Ellagic acid (10, 20 and 40 mg/kg, po) was administered for 21 ...

Ellagic acid has been demonstrated to inhibit the growth of several types of cancer cells. However, whether it sensitizes human colorectal carcinoma cells to 5-fluorouracil, has not yet been investigated. Colorectal carcinoma HT-29, Colo 320DM, SW480 and LoVo cells were treated with ellagic acid (2.5-25 μg/ml) and 5-fluorouracil (5-25 μM) alone and in combination and then the viability was asse...

Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have reported that other compounds in the berries may also contribute to the observed in...

This study aimed to assess the potential anti-angiogenic mechanism of Phyllanthus urinaria (P. urinaria) and characterize the major compound in P. urinaria that exerts anti-angiogenic effect. The water extract of P. urinaria and Ellagic Acid were used to evaluate the anti-angiogenic effect in chorioallantoic membrane (CAM) in chicken embryo and human vascular endothelial cells (HUVECs). The ma...