A novel structural solid dispersion (SD) taking the form of core-shell microparticles for poorly water-soluble drugs is reported for the first time. Using polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix, the SDs were fabricated using coaxial electrospraying (characterized by an epoxy-coated concentric spray head), although the core fluids were unprocessable using one-fluid electrospr...

Poly(lactic-co-glycolic acid) (PLGA) microspheres containing celecoxib were prepared via electrospraying, and the influence of three processing parameters namely flow rate, solute concentration and drug loading, on the physico-chemical properties of the particles and the drug-release profile was studied. Microspheres with diameters between 2 and 8 μm were produced and a near-monodisperse size d...

Sustained release is highly desired for “efficacious, safe and convenient” drug delivery, particularly those anticancer molecules with toxicity. In this study, a modified coaxial electrospraying process was developed to coat hydrophobic lipid, i.e., stearic acid (SA), on composites composed of the tamoxifen citrate (TC) insoluble polymeric matrix ethylcellulose (EC). Compared electrosprayed TC-...