GOLUB, M. S., M. L. CHEAL AND R. E. DAWS. Effects of electroconvulsive shock and puromycin on operant responding in goldfish. Pt-~SIOL. Bm-IAV. 8 (4) 573-578, 1972.--Goldfish were conditioned to strike an operandum for food reward on a variable interval schedule. Well-established patterns of operant responding were disrupted for up to several days when the fish were convulsed by a 1 sec transcr...

OBJECTIVES Electroconvulsive shock therapy (ECT) has been widely used as an effective and established treatment for refractory depression and schizophrenia. Some reports have shown that ECT is also effective for treating refractory neuropathic pain. DESIGN In a rat model of neuropathic pain produced by chronic constrictive injury (CCI) of the sciatic nerve, thermal hyperalgesia, and mechanica...

The effects of chronic treatment with desimipramine (a tricyclic antidepressant), fluoxetine [a specific 5-hydroxytryptamine (5-HT) uptake inhibitor], clorgyline (a specific monoamine oxydase inhibitor of A type), ipsapirone (a specific 5-HT1A receptor agonist) as well as electroconvulsive shock treatment were investigated on rat hippocampal 5-HT1A receptors negatively coupled to adenylyl cycla...

In the recent years there has been an increased interest in the pyridazinone ring system. Many investigations indicated that the presence of at least one aryl group, one or two electron donor atoms and/or an NH group in a special spatial arrangement is necessary for anticonvulsant activity. Many investigations indicated that the presence of at least one aryl group, one or two electron donor ato...