A new antibiotic, victomycin, is active against a variety of Gram-positive and Gram-negative bacteria, and also has in vivo activity against solid Sarcoma 180 and Ehrlich ascites carcinoma. It belongs to the phleomycin-bleomycin group of antibiotics and has been differentiated from all known phleomycins and bleomycins by its physicochemical properties and thin-layer chromatograms.

A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma.

Antitumor activity of the adduct between Carboplatin and alpha-cyclodextrin has been tested against Sarcoma 180 (S(180)) and Ehrlich ascites carcinoma (EAC) murine tumors. The preliminary toxicity has also been evaluated by histological examinations of the treated animals. The results show the adduct has less antitumor efficacy than and similar toxicity to Carboplatin.

The effects of a number of alkylating agents on the in vitro incorporation of glycine1-C ~4 into the ethanol/acetone-insoluble fraction of Ehrlich ascites carcinoma cells have been studied. With the exception of 1:6-dimethanesulfonyl-D-mannitol, all inhibit (at the concentrations tested) this incorporation in varying degrees, with little or no effect on the respiration of the cells. The process...

The Ehrlich mouse ascites tumor has become one of the widely used experimental cancers, par ticularly, as pointed out by Klein (6), in those studies dealing with quantitative aspects of tu mor biology. This tumor has been studied exten sively by a number of previous investigators. Loewenthal and Jahn (11) found that intraperitoneal inoculation with organ brei containing the Ehrlich carcinoma pr...

The loosely bound chromatin proteins of Ehrlich ascites hyperdiploid cells have been prepared by extraction of chromatin with 0.35 M NaCl. Sodium dodecyl sulfate gel electrophoresis of the 0.35 M NaCl-soluble chromatin proteins reveals high heterogeneity with a molecular weight range of 10,000 to 170,000. The 0.35 M NaCl-soluble chromatin proteins contain many components similar to the more tig...

Sir: In our screening programme for an antitumor agent using the mouse Ehrlich ascites tumor, it was found that fatty acids extracted from some fungal mycelia showed significant antitumor activity in vivo. In primary screening, the acetone extracts of the mycelia of Penicillium crustosum IAM 7014, Pen. tardum IAM 7206, Caphalosporium diospyri and Sepedonium ampullosporum showed antitumor activi...