Based on a review of the Enhanced Geothermal Systems (EGS) developed to date, numerical simulation of idealized EGS reservoirs, economic sensitivity analysis, and practical considerations of certain site characteristics, this paper shows that certain steps can be taken towards optimizing the economics of an EGS project: These steps, in decreasing order of their importance, are as follows: (a) r...

This paper describes a constraint transformation approach to automatic example generation and its implementation. In this approach examples are generated as the result of successive transformations of the constraint formulas. Such transformations are carried out based on various forms of knowledge. Systematic global simplification, largely based on declarative knowledge, mitigates the impact of...

External guide sequences (EGSs) are small RNA molecules which consist of a sequence complementary to a target mRNA and render the target RNA susceptible to degradation by ribonuclease P (RNase P). EGSs were designed to target the mRNA encoding thymidine kinase (TK) of herpes simplex virus 1 for degradation. These EGSs were shown to be able to direct human RNase P to cleave the TK mRNA sequence ...

In a model selection procedure where many models are to be compared, computational efficiency is critical. For acyclic digraph (ADG) Markov models (aka DAG models or Bayesian networks), each ADG Markov equivalence class can be represented by a unique chain graph, called an essential graph (EG). This parsimonious representation might be used to facilitate selection among ADG models. Because EGs ...

The deliberate inhibition of expression of one of the protein subunits (Rpp38) of human nuclear RNase P is achievable by using external guide sequence (EGS) technology. Both the protein product and the mRNA are greatly reduced 24 h after transient transfection with a gene coding for an appropriate EGS. Control experiments indicated that four other protein subunits of RNase P and their RNAs are ...

Gamification is the concept of applying game elements in non-game context platforms to motivate people to participate in planned activities to achieve goals. Gamification has been applied to academic fields including software engineering (SE) in recent years. Many gamification implementations in SE have been ad hoc and lacked standardized guidelines. This paper introduces a new concept of build...

Induced seismicity has been recognized as a concern in subsurface industrial operation, and particularly at fluid-injection sites in major oil and gas exploitation plays, where hydraulic stimulations are conducted to increase rock permeability. Induced seismicity occurs also in Enhanced Geothermal Systems (EGS), where hydraulic fracturing is used to accelerate heat extraction from the rock. If ...

Increasing numbers of older patients require Emergency admission under General Surgery (EGS). This is a group of heterogeneous and often complex individuals with varying degrees of multimorbidity, polypharmacy, functional, mobility and cognitive impairment. Our article describes the benefits of comprehensive assessment coupled with patient-centred multiprofessional interventions and timely disc...

Objective. To provide a method to improve the development and maintainability costs of composite Educational Guidelines (EG) by decomposing decision tables represented as concept lattices. Background. The development of complex didactic content of EG has been shown to require a specific formalism as compared to the one of traditional guidelines. The personalization of EGs’ content according to ...

By now it is well recognized that the instrument of rural works programs (RWPs) has become an important component of strategies to alleviate poverty and hunger in many developing countries. The case for RWPs lies in the self-targeting nature of the schemes (see Dreze and Sen 1990; Ravallion 1991; Besley and Coate 1992; Besley and Kanbur 1993). Also, discriminations prevalent in some agricultura...