نتایج جستجو برای: ebola virus

تعداد نتایج: 400131  

Journal: :The Lancet 2017
Thomas W Geisbert

www.thelancet.com Published online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32618-6 1 Since the discovery of Ebola virus in 1976, researchers have attempted to develop eff ective vaccines. Early eff orts were largely stalled as a result of the small global market for a vaccine for Ebola virus disease because of an absence of fi nancial incentives for pharmaceutical companies. A...

Journal: :Journal of virology 2005
Akihito Yonezawa Marielle Cavrois Warner C Greene

The Ebola filoviruses are aggressive pathogens that cause severe and often lethal hemorrhagic fever syndromes in humans and nonhuman primates. To date, no effective therapies have been identified. To analyze the entry and fusion properties of Ebola virus, we adapted a human immunodeficiency virus type 1 (HIV-1) virion-based fusion assay by substituting Ebola virus glycoprotein (GP) for the HIV-...

Journal: :Journal of virology 2002
Carmen P Alvarez Fátima Lasala Jaime Carrillo Oscar Muñiz Angel L Corbí Rafael Delgado

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting ...

Journal: :Journal of virology 2001
P Pushko J Geisbert M Parker P Jahrling J Smith

Lassa and Ebola viruses cause acute, often fatal, hemorrhagic fever diseases, for which no effective vaccines are currently available. Although lethal human disease outbreaks have been confined so far to sub-Saharan Africa, they also pose significant epidemiological concern worldwide as demonstrated by several instances of accidental importation of the viruses into North America and Europe. In ...

Journal: :The Lancet. Infectious diseases 2016
Julius Schachter Joan M Chow

www.thelancet.com/infection Vol 16 September 2016 989 5 WHO. Interim guidance: clinical care for survivors of Ebola virus disease, 11 April 2016. http://apps.who.int/iris/bitstream/10665/204235/1/WHO_ EVD_OHE_PED_16.1_eng.pdf (accessed April 29, 2016). 6 WHO. Emergency response to Ebola fl are underway in Liberia. Case investigation widens to Guinea. 2016. http://who.int/csr/disease/ ebola/libe...

Journal: :Lancet 2011
Heinz Feldmann Thomas W Geisbert

Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man, designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The exception is the species Reston Ebola virus, which has not been associated with human disease and is found in the Philippines. Ebola virus constitutes an important local public health threat in Africa, with a worldwide...

Journal: :Emerging infectious diseases 2016
Robert J Fischer Seth Judson Kerri Miazgowicz Trent Bushmaker Vincent J Munster

On March 20, 2015, a case of Ebola virus disease was identified in Liberia that most likely was transmitted through sexual contact. We assessed the efficiency of detecting Ebola virus in semen samples by molecular diagnostics and the stability of Ebola virus in ex vivo semen under simulated tropical conditions.

2015
Bethany A. Rhein Linda S. Powers Kai Rogers Manu Anantpadma Brajesh K. Singh Yasuteru Sakurai Thomas Bair Catherine Miller-Hunt Patrick Sinn Robert A. Davey Martha M. Monick Wendy Maury Matthias Johannes Schnell

Ebola virus outbreaks, such as the 2014 Makona epidemic in West Africa, are episodic and deadly. Filovirus antivirals are currently not clinically available. Our findings suggest interferon gamma, an FDA-approved drug, may serve as a novel and effective prophylactic or treatment option. Using mouse-adapted Ebola virus, we found that murine interferon gamma administered 24 hours before or after ...

Journal: :Journal of virology 1998
R J Wool-Lewis P Bates

Studies analyzing Ebola virus replication have been severely hampered by the extreme pathogenicity of this virus. To permit analysis of the host range and function of the Ebola virus glycoprotein (Ebo-GP), we have developed a system for pseudotyping these glycoproteins into murine leukemia virus (MLV). This pseudotyped virus, MLV(Ebola), can be readily concentrated to titers which exceed 5 x 10...

Journal: :Critical care medicine 2015
Viranuj Sueblinvong Daniel W Johnson Gary L Weinstein Michael J Connor Ian Crozier Allison M Liddell Harold A Franch Bruce R Wall Andre C Kalil Mark Feldman Steven J Lisco Jonathan E Sevransky

OBJECTIVE This report describes three patients with Ebola virus disease who were treated in the United States and developed for severe critical illness and multiple organ failure secondary to Ebola virus infection. The patients received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for Ebola virus disease. DATA SOURC...

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