Neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. Although recent medical advances have improved neonatal care, many challenges remain in the diagnosis and management of neonatal infections. The diagnosis of neonatal sepsis is complicated by the frequent presence of noninfectious conditions that resemble sepsi...

introduction early diagnosis of neonatal sepsis is essential for successful treatment. blood culture is a gold standard for diagnosis but the final results are not available until 48-72 hours after culture. interleukin-6 (il-6) as a marker plays a critical role in the induction of c-reactive protein (crp) synthesis in the liver. it has been hypothesized that this cytokine could be detected in b...

Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations.We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive prediction of early neonatal sepsis. A follow-up study was performed clinical signs of sepsis or maternal risk factors for sepsis. Neonates were ass...

BACKGROUND Neonatal sepsis is a worldwide public health issue in which, depending on the studied population, marked variations concerning its risk and prognostic factors have been reported. The aim of this study was to assess risk and prognostic factors for neonatal sepsis prevailing at a medical unit in southeastern Mexico. Thus, we used a historic cohort design to assess the association betwe...

Background Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis. Materials and Methods: A search of online databases (Medl...

Neonatal early-onset sepsis (EOS) continues to be a significant source of morbidity and mortality among newborns, especially among very-low birthweight infants. Epidemiologic risk factors for EOS have been defined, and considerable resources are devoted to the identification and evaluation of infants at risk for EOS. The widespread implementation of intrapartum antibiotic prophylaxis for the pr...

In an ideal world, the practice of medicine would be based on scientific studies guiding the decisions involved in the care of an individual patient. However, clinicians must frequently rely on observational studies and the experiences of other practitioners (the “art of medicine”) because high-quality randomized clinical trials are not available. Within the field of pediatrics, nowhere is that...

Brief History of the Present Illness A 6-day-old female with septic shock was admitted to the hospital in the fall. Two days before admission, she had developed a macular rash on her face and extremities that was attributed to a normal newborn rash. She also had difficulty with breastfeeding, and her mother started formula supplementation upon suggestion by her pediatrician. Over the next 48 ho...

S sepsis is a common cause of morbidity and mortality in neonates. In a population-based surveillance study1 from 2005 to 2008, researchers estimated that 3300 cases of early-onset sepsis (EOS) occur in the United States each year, with 390 of these cases resulting in death. The risk is highest in preterm neonates, which account for 1570 of the 3300 cases and 360 deaths.1 Despite its prevalence...