Previous examination of the accessibility of a panel of single-Cys mutants in transmembrane domain III (TMDIII) of the yeast mitochondrial citrate transport protein to the hydrophilic, cysteine-specific methanethiosulfonate reagent MTSES enabled identification of the water-accessible surface of this TMD. Further studies on the effect of citrate on MTS reagent accessibility, indicated eight site...

Elephant Endotheliotropic Herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants, an endangered species. One hypothesis to explain this vulnerability of some juvenile elephants is that they fail to mount an effective T cell response to the virus. To our knowledge, there have been no studies of Asian elephant T cell responses to EEHV. To address this deficiency, we v...

Background Janus kinase (JAK) inhibitor is a great addition to the therapeutic options for rheumatoid arthritis (RA). However, clinical efficacy and safety of tofacitinib comparing with methotrexate (MTX) was not elucidated. Objectives We conducted controlled randomized trial in treatment naive (RA) patients explore (TOFA) MTX. Methods In this open-label, randomized, trial, RA at status medium ...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

e34 www.thelancet.com Vol 382 December 7, 2013 The world has changed radically since the World Development Report (WDR) Investing in Health was published 20 years ago, so it is valuable and timely to look ahead once again. The Lancet Commission’s optimistic report on investing in health confi rms my view that the best times for public health are still ahead of us. As we debate the place of heal...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

February 2006 | Volume 4 | Issue 2 | e41 | e34 One of the most surprising discoveries in molecular biology was that a gene’s coding region is broken up into smaller pieces (the exons) interrupted by noncoding portions called introns. After the DNA is transcribed into RNA, and before the RNA can leave the nucleus, the introns must be cut out and the exons spliced together. Since introns were dis...

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