نتایج جستجو برای: e3

تعداد نتایج: 11331  

Journal: :The Journal of clinical investigation 2002
Reza Mazhari H Bradley Nuss Antonis A Armoundas Raimond L Winslow Eduardo Marbán

Regulatory subunit KCNE3 (E3) interacts with KCNQ1 (Q1) in epithelia, regulating its activation kinetics and augmenting current density. Since E3 is expressed weakly in the heart, we hypothesized that ectopic expression of E3 in cardiac myocytes might abbreviate action potential duration (APD) by interacting with Q1 and augmenting the delayed rectifier current (I(K)). Thus, we transiently coexp...

2010
Melda Tozluoglu Ezgi Karaca Ruth Nussinov Turkan Haliloglu

Sumoylation, the covalent attachment of SUMO (Small Ubiquitin-Like Modifier) to proteins, differs from other Ubl (Ubiquitin-like) pathways. In sumoylation, E2 ligase Ubc9 can function without E3 enzymes, albeit with lower reaction efficiency. Here, we study the mechanism through which E3 ligase RanBP2 triggers target recognition and catalysis by E2 Ubc9. Two mechanisms were proposed for sumoyla...

Journal: :Journal of virology 2008
Brian P McSharry Hans-Gerhard Burgert Douglas P Owen Richard J Stanton Virginie Prod'homme Martina Sester Katja Koebernick Veronika Groh Thomas Spies Steven Cox Ann-Margaret Little Eddie C Y Wang Peter Tomasec Gavin W G Wilkinson

The adenovirus (Ad) early transcription unit 3 (E3) encodes multiple immunosubversive functions that are presumed to facilitate the establishment and persistence of infection. Indeed, the capacity of E3/19K to inhibit transport of HLA class I (HLA-I) to the cell surface, thereby preventing peptide presentation to CD8(+) T cells, has long been recognized as a paradigm for viral immune evasion. H...

Journal: :Archives of histology and cytology 1995
K Terao M Kotani

Mouse fetal livers of 12 days gestation were transplanted beneath the kidney capsule of syngeneic castrated male hosts. Recipients received a single intraperitoneal injection of 5 mg estriol (E3) immediately after transplantation and were sacrificed 4, 7 and 14 days later. Control mice received injections of solvent only. The fetal liver grafts of the E3 groups showed remarkable growth compared...

2018
Arlene J. George Yarely C. Hoffiz Antoinette J. Charles Ying Zhu Angela M. Mabb

Protein ubiquitination is a posttranslational modification that plays an integral part in mediating diverse cellular functions. The process of protein ubiquitination requires an enzymatic cascade that consists of a ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2) and an E3 ubiquitin ligase (E3). There are an estimated 600-700 E3 ligase genes representing ~5% of the human geno...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1971
B W Senior I B Holland

The properties of 30S ribosomal subunits from untreated and from colicin E3-treated (E3-30S) bacteria have been compared. Polyacrylamide gel electrophoresis of ribosomal proteins revealed no difference, but several studies indicated that the 16S RNA from E3-30S particles was modified. E3-16S RNA showed slightly increased resistance to heat-induced degradation and had a reduced (15 S) sedimentat...

Journal: :Molecular Cell 2007

2017
Soo Chil Lee Young-Won Kwon Ju-Yeon Park Sung Yun Park Ju-Hee Lee Sun-Dong Park

SC-E3 is a novel herbal formula composed of five oriental medicinal herbs that are used to treat a wide range of inflammatory diseases in Korean traditional medicine. In this study, we sought to determine the effects of SC-E3 on free radical generation and inflammatory response in lipopolysaccharide- (LPS-) treated RAW 264.7 macrophages and the molecular mechanism involved. The ethanol extract ...

Journal: :Food bioscience 2022

This study aimed to in vitro evaluate the impact of common gastrointestinal (GI) alterations appearing with aging on protein digestibility, and functional related properties, four different meats (chicken, turkey, pork beef). Thus, three elderly digestion models were stated as long altered GI conditions affected at oral (E1), gastric (E2) oral, intestinal stages (E3). Healthy adult also mimicke...

Journal: :European journal of endocrinology 2003
B Seidel A Glasow M Schutt W Kiess Z Wu C J Strasburger J Kratzsch

OBJECTIVE The human GH-binding protein (GHBP) is derived from the GH receptor (GHR) through proteolytic cleavage of its extracellular domain. Two isoforms of the GHBP exist, differing in the retention or exclusion of exon 3: E3(+)GHBP and E3(-)GHBP. Our study aimed to answer the questions whether the level of E3(+)GHBP in the serum correlates with the GHR exon 3 expression and whether or not th...

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