Freezing injury to the cortical plate of the newborn rat results in the formation of a focal region of cerebrocortical microdysgenesis resembling, in many ways, human 4-layered microgyria. Previous research has shown that neurons born during embryonic day (E) 20 migrate through the initial damage and take their place in the cell-dense layer of the microgyric lesion. The current study was conduc...

AIM To investigate the toxic effects of mid-pregnancy cocaine exposure on embryo-fetus. METHODS A transplacental murine model of cocaine exposure on embryo-fetus mice was established, in which pregnant dams of comparable weight were assigned into three groups: cocaine with food ad lib (COC), saline and pair-fed with COC (SPF), and saline with food ad lib (SAL). From embryonic d 8 (E8) to E17,...

Scaffolds derived from decellularized tissues provide a natural microenvironment for cell culture. Embryonic cerebrospinal fluid (e-CSF) contains factors which play vital roles in development of the nervous system. This research was aimed to survey the effect of Wistar rat e-CSF on neural differentiation of bone marrow derived mesenchymal stem cells (BM-MSCs) cultured on the human amniotic memb...

hippocampal neural stem/progenitor cells (hipp-ns/pcs) of the adult mammalian brain are important sources of neuronal and gial cell production. in this study, the main goal is to investigate the plasticity of these cells in neuronal/astroglial differentiations. to this end, the differentiation of the hipp-ns/pcs isolated from 3-month-old wistar rats was investigated in response to the embryonic...

Hippocampal neural stem/progenitor cells (hipp-NS/PCs) of the adult mammalian brain are important sources of neuronal and gial cell production. In this study, the main goal is to investigate the plasticity of these cells in neuronal/astroglial differentiations. To this end, the differentiation of the hipp-NS/PCs isolated from 3-month-old Wistar rats was investigated in response to the embryonic...

References 1. Ebihara K, Tachibe M, Kaneko N, et al. (2013) Hydroxypropylation of high-amylose maize starch changes digestion and fermentation-dependent parameters in rats. J Nutr Sci 2, e17 doi:10.1017/jns.2013.5. 2. Kabeerdoss J, Ferdous S, Balamurugan R, et al. (2013) Development of the gut microbiota in southern Indian infants from birth to 6 months: a molecular analysis. J Nutr Sci 2, e18 ...

Neutron radiation, a high-linear energy transfer has high relative biological effectiveness (RBE) for various end points. The age at exposure is an important modifier of the effects including carcinogenesis, with infants being generally more radiosensitive. Ptch1+/– mice offer unique experimental system assessing radiation carcinogenesis. Spontaneous development medulloblastoma tumors occurs in...

Apoptosis induced by ionizing irradiation of the developing mouse brain was investigated by using histology, analysis of DNA fragmentation on agarose gel and electron microscopy. A TUNEL-labeled index (L.I.) was calculated from the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay in 4 specific regions, cortical plate, intermediate zone, subependymal zone...