The Rho/ROCK pathway is involved in numerous pivotal cellular processes that have made it an area of intense study in cancer medicine, however, Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors are yet to make an appearance in the clinical cancer setting. Their performance as an anti-cancer therapy has been varied in pre-clinical studies, however, they have been shown to be...

The presence of circulating tumor cells (CTCs) in blood predicts poor patient outcome and CTC frequency is correlated with higher risk of metastasis. Recently discovered, novel microtubule-based structures, microtentacles, can enhance reattachment of CTCs to the vasculature. Microtentacles are highly dynamic membrane protrusions formed in detached cells and occur when physical forces generated ...

The snake is a potent entity in many cultures across the world, and is a noticeable global theme in rock art and inscribed landscapes. We mobilise our long-term ethnographic research with southern African KhoeSan peoples to situate and interpret the presence of snake motifs in the region’s rock art. We contextualise the snake as a transformative ontological mediator between everyday and “entran...

Fluid flow in porous media is a dynamic process that is traditionally modeled using PDE (Partial Differential Equations). In this approach, physical properties related to fluid flow are inferred from rock sample data. However, due to the limitations posed in the sample data (sparseness and noise), this method often yields inaccurate results. Consequently, production information is normally used...

l f Discominuity persistence has a major effect on rock mass resistance (strength) but, as direct mapping ofdiscominuities imemal to a rock mass is not possible, persistence is a difficult parameter to measure. As a result, the conservative approach of assuming full persistence is often taken. /n this paper a method is developed for relating rock mass stability and hence persistence to the geom...

The use of a three dimensional Discrete Element Method (DEM) is proposed to study concrete submitted to rock-fall impacts. The model has already been validated through quasi-static, as well as dynamic simulations (SHPB tests). The simulation of four-point beam bending tests has validated the introduction of the reinforcement in the model. With this approach all the local parameters can be ident...

The global earthquake disaster happened frequently in recent years, how to guide the construction correctly in seismic area becoming a problem to be solved, while the study on the tunnel geological advanced prediction system in seismic area is limited. This paper established an integrated prediction system which was combined with engineering geology analysis and geophysical method combined with...