We show the compatibility between the moderate or nearby cycle functor for regular holonomic D-modules, as defined by Beilinson, Kashiwara and Malgrange, and the Hermitian duality functor, as defined by Kashiwara. Introduction The Hermitian dual of a D-module was introduced by M. Kashiwara in [9], who showed that the Hermitian dual of a regular holonomic D-module is also regular holonomic (henc...

Diffusional permeability (P) to inulin (P(in)), albumin (P(alb)), and dextrans [70 (P(dx 70)), 150 (P(dx 150)), 550 (P(dx 550)), and 2, 000 (P(dx 2,000))] was determined in specimens of parietal pericardium of rabbits, which may be obtained with less damage than pleura. P(in), P(alb), P(dx 70), P(dx 150), P(dx 550), and P(dx 2, 000) were 0.51 +/- 0.06 (SE), 0.18 +/- 0.03, 0.097 +/- 0.021, 0. 04...

THREE DOCETAXEL (DX) LIPID CONJUGATES: 2'-lauroyl-docetaxel (C12-DX), 2'-stearoyl-docetaxel (C18-DX), and 2'-behenoyl-docetaxel (C22-DX) were synthesized to enhance drug loading, entrapment, and retention in liquid oil-filled lipid nanoparticles (NPs). The three conjugates showed ten-fold higher solubility in the liquid oil phase Miglyol 808 than DX. To further increase the drug entrapment effi...

‎Suppose that $X_{t}$ is a one-dimensional and real-valued L'evy‎ ‎process started from $X_0=0$‎, ‎which ({bf 1}) its nonnegative‎ ‎jumps measure $nu$ satisfying $int_{Bbb‎ ‎R}min{1,x^2}nu(dx)

By using averaging functions, several new oscillation criteria are established for the half-linear damped differential equation-2-2-2-2 r(t) (x) +p(t) |x| x,r(t) (x) +q(t)|x| x=0, dx dx dx dx dt dt dt dt α α α α ψ ϕ ψ ⎛ ⎞ ⎛ ⎞ ⎜ ⎟ ⎜ ⎟ ⎜ ⎟ ⎜ ⎟ ⎝ ⎠ ⎝ ⎠ and the more general equation-2-2 r(t) (x) +p(t) g(x),r(t) (x) +q(t)g(x)=0, d dx dx dx dx dt dt dt dt dt α α ψ ϕ ψ ⎛ ⎞ ⎛ ⎞ ⎜ ⎟ ⎜ ⎟ ⎜ ⎟ ⎜ ⎟ ⎝ ⎠ ⎝ ⎠ ...

Blood loss is the major cause of postoperative mortality and morbidity associated with hepatic resection. A prospective multicenter study was conducted to determine if ultrasonic dissectors (USD) were useful in hepatic resection and could reduce this hemorrhagic risk. Forty-seven hepatic resections were performed in 42 consecutive patients during a two month period in 11 public, surgical center...

INTRODUCTION Breast cancer is the most common malignancy among Turkish women and the rate of early stage disease is increasing. The Oncotype DX(®) 21-gene assay is predictive of distant recurrence in ER-positive, HER2-negative early breast cancer. We aimed to evaluate the impact of the Recurrence Score(®) (RS) on treatment decisions and physician perceptions in Turkey. We also studied correlati...

Oxysterol like 27-hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype. We examined whether dexamethasone (Dx) affects 27OHChol-induced differentiation using THP-1 cells. Treatment of monocytic cells with Dx resulted in almost complete inhibition of transcription and surface expression of CD80, CD83, and CD88 induced...

Let t (dx) denote a three dimensional super-Brownian motion with deterministic initial state 0 (dx) = dx, the Lebesgue measure. Let V : R 3 7 ! R be HH older continuous with compact support, not identically zero and such that Z R 3 V (x)dx = 0. We show that log P Z t 0 Z R 3 V (x) s (dx)ds > bt 3=4 is of order t 1=2 as t ! 1, for b > 0. This should be compared with the known result for the case...

PURPOSE To assess the maximum-tolerated dose, toxicity, and pharmacokinetics of DE-310, a macromolecular prodrug of the topoisomerase I inhibitor exatecan (DX-8951f). in patients with advanced solid tumors. EXPERIMENTAL DESIGN Patients received DE-310 as a 3-hour infusion once every 2 weeks (dose, 1.0-2.0 mg/m(2)) or once every 6 weeks (dose, 6.0-9.0 mg/m(2)). Because pharmacokinetics reveale...