Large-conductance voltage- and Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) excitability and contractility. PKC modulates the contraction of DSM and BK channel activity in non-DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown. We provide a novel mechanistic insight into BK channel regulation...

The proposed revision for Autism spectrum disorders (ASDs) in the Diagnostic and Statistical Manual of Mental Disorders--Fifth Edition (DSM-5) represents a shift from the Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition, Text Revision (DSM-IV-TR). As the proposed DSM-5 criteria require a higher minimum number of symptoms to be present compared to DSM-IV-TR, there have been ...

In 2013, the American Psychiatric Association (APA) published 5th edition of its Diagnostic and Statistical Manual Mental Disorders (DSM-5). 2019, World Health Assembly approved 11th revision International Classification Diseases (ICD-11). It has often been suggested that field would benefit from a single, unified classification mental disorders, although priorities constituencies two sponsorin...