Chondroitin sulfate (CS) and dermatan sulfate (DS) are expressed in significant amounts in the brain and play important roles in the development of the central nervous system in mammals. CS and DS structures are often found in a single CS/DS hybrid chain. The l-iduronic acid (IdoA)-containing domain, which defines a DS-type domain, appears key to the biological functions of the CS/DS hybrid cha...

Two species of dermatan sulfate proteoglycans, called DS-PGI and DS-PGII, have been isolated from mature bovine articular cartilages. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis at low ionic strength in 0.01 M phosphate the dermatan sulfate proteoglycans appeared as a single polydisperse species whose molecular weight ranged from 80,000 to 140,000. The dermatan sulfate proteogl...

A search for double-heavy tetraquark state candidates Xccs¯s¯ decaying to Ds+Ds+ and Ds*+Ds*+ is presented the first time using data samples of 102×106 ϒ(1S) 158×106 ϒ(2S) events, at s=10.52, 10.58, 10.867 GeV corresponding integrated luminosities 89.5, 711.0, 121.4 fb−1, respectively, accumulated with Belle detector KEKB asymmetric energy electron-positron collider. The invariant-mass spectra ...

A search for double-heavy tetraquark state candidates Xccs¯s¯ decaying to Ds+Ds+ and Ds*+Ds*+ is presented the first time using data samples of 102×106 ϒ(1S) 158×106 ϒ(2S) events, at s=10.52, 10.58, 10.867 GeV corresponding integrated luminosities 89.5, 711.0, 121.4 fb−1, respectively, accumulated with Belle detector KEKB asymmetric energy electron-positron collider. The invariant-mass spectra ...

Children with Down syndrome (DS) have an increased risk for leukemia. The prognosis for DS acute myeloid leukemia (AML) is better than for non-DS AML, but the clinical outcome of DS acute lymphoblastic leukemia (ALL) is equal to that of non-DS ALL. Differences in prognosis may reflect differences in cellular drug resistance. In vitro drug resistance profiles were successfully investigated on le...

Protein synthesis initiation in reticulocyte lysates is inhibited by low concentrations (1-20 ng/ml) of double-stranded RNA (ds RNA) due to the activation of a ds RNA-dependent cAMP-independent protein kinase (ds I) that phosphorylates the alpha subunit of the eukaryotic initiation factor eIF-2. In lysates, ds I is present in the latent inactive form and is associated with the ribosome compleme...

Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). CBR1 is located in the DS critical region (21q22.12). The expression of CBR1 in hearts from individuals with DS has not been charac...

Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). CBR1 is located in the DS critical region (21q22.12). The expression of CBR1 in hearts from individuals with DS has not been charac...