In the drug development process, candidate compounds are first screened for desirable biological properties such as effects on gene expression, signal transduction, or enzyme activity. The genetic and metabolic pathways used in the readouts are known as targets of the drug screening process. Despite advances in molecular targeting, proteomics and metabolomics, drug screening with molecular or m...

Schematic representation of the methodology developed for creating cryopreservable high throughput paper-based arrays 3D tumor models drug screening applications.

We investigated the effect of efavirenz treatment on the results of drug screening tests of urine samples obtained from 100 patients infected with human immunodeficiency virus. Of 50 patients who received efavirenz, 49 tested positive for benzodiazepines in > or =1 drug screening test, whereas of 50 patients who did not receive efavirenz, only 1 tested positive for benzodiazepines in > or =1 dr...

BACKGROUND: The Patient Protection and Affordable Care Act of 2010 supports integration of substance abuse interventions and treatments into the mainstream health care system. Thus, effective screening and intervention for substance use disorders in health care settings is a priority. OBJECTIVE: This paper reviews the prevalence of alcohol and drug use disorders (abuse or dependence) in primar...

As a superfamily of enzymes, proteases play critical roles in the regulation of cellular protein activity. There are nearly 500 known human proteases, and over 100 identified homologs. It is estimated that up to 1,200 human genes encode proteases. Therefore, proteases constitute a particularly important class of protein targets of interest to drug discovery screening programs in the biopharmace...

INTRODUCTION From a drug discovery point of view, ion channels are very interesting and challenging targets. Over the past decade, great efforts have been made in developing platforms for patch clamp-based high-quality screening of ion channels in discovering new drug candidates as well for evaluating their safety profiles. Indeed, the automated patch clamp (APC) has recently reached the data t...