 The physicochemical properties of the drug substance can assume a primary role in controlling its dissolution from the dosage form.  The aqueous solubility of the drug is one of the major factors that determine its dissolution rate.  Some studies concluded that the drug solubility data can be used as rough predictor of the possibility of any future problems with bioavailability.  Some of t...

I. Introduction The US Food and Drug Administration sets performance limit on dissolution in terms of a specific percentage Q that the drug product is required to be dissolved at a specified time. Based on inferences from correlated bioavailability studies, these dissolution specifications were intended to assure that at least 80% of the labeled quantity of drug was available. When carried out ...

The aim of this study was to develop a novel microbially triggered and animal-sparing dissolution method for testing of nanorough polysaccharide-based micron granules for colonic drug delivery. In this method, probiotic cultures of bacteria present in the colonic region were prepared and added to the dissolution media and compared with the performance of conventional dissolution methodologies (...

Chlordiazepoxide, a member of the 1, 4-benzodiazepine, showing poor aqueous solubility and dissolution rate in water, so the present work was focused to prepare the microspheres of Chlordiazepoxide to improve its solubility and dissolution; using chitosan with different drug: polymer ratio by spray-drying technique. The effect of different drug: polymer ratio on the solubility and dissolution o...

Drug absorption in the human body depends on the dissolution rate of the drug. Suitable dissolution characteristics are important to ensure that the drug will achieve the desired therapeutic effects. To assess the similarity of dissolution rates of several drug lots, we apply a general growth curve model with different covariance structures. The Box-Cox power transformation and the naive log tr...

The objective of the present investigation was to study the effect of polyethylene glycol 4000 (PEG 4000) on in vitro dissolution of gliclazide from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the melting or fusion method.Phase and saturation solubility study, in vitro dissolution of pure drug, physical ...

Dissolution tests that can predict the in vivo performance of drug products are usually called biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects on the dissolution and bioavailability of orally administered drugs, and to identify solubility limitations and stability issues. To develop a biorelevant dissolution t...

Purpose: The aim of present study was to improve the dissolution rate of poorly soluble drug Loperamide (LPM) by liquisolid compact technique. Methods: Liquisolid compacts of LPM were prepared using Propylene glycol (PG) as a solvent, Avicel pH 102 as carrier, Aerosil as coating material and Sodium Starch Glycolate (SSG) as superdisintegrant. Interactions between the drug and excipients were ex...

The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. The purpose of this research was to obtain enhancement of the dissolution profile of Mefenamic acid (MA) using solid dispersion technique with hydrophilic polymers such as poly ethylene glycol (PEG), polyvinyl pyrrolidone (PVP)...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...