Extended longevity is often correlated with increased resistance against various stressors. Insulin/IGF-1-like signaling (IIS) is known to have a conserved role in aging and cellular mechanisms against stress. In C. elegans, genetic studies suggest that heat-shock transcription factor HSF-1 is required for IIS to modulate longevity. Here, we report that the activity of HSF-1 is regulated by IIS...

On account of its many successes in inference tasks and imaging applications, Dictionary Learning (DL) related sparse optimization problems have garnered a lot research interest. In DL area, most solutions are focused on single-layer dictionaries, whose reliance handcrafted features achieves somewhat limited performance. With the rapid development deep learning, improved methods called Deep (DD...

This paper presents an overview of the MPEG-7 Description Definition Language (DDL). The DDL provides the syntactic rules for creating, combining, extending and refining MPEG-7 Descriptors (Ds) and Description Schemes (DSs). In the interests of interoperability, the W3C’s XML Schema language, with the addition of certain MPEG-7-specific extensions, has been chosen as the DDL. This paper describ...

The present paper, framed within the ECTS scheme currently being piloted at the University of Jaén, reports on a study carried out in the second semester of the academic year 2004-5 with English Philology freshmen at this University. One of its aims, described in an initial section of the paper, was to determine whether the use of Computer Assisted Language Learning (CALL), and DataDriven Learn...

D-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes D-alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). Previously, we demonstrated that the overproduction of Alr in Mycobacterium smegmatis determines a DCS resistance phenotype. In this study, we investigated the roles of both Alr and Ddl in the mechanisms of action of and resistance to DCS in M. smegmatis. We found th...

This paper describes a domain description language DDL.1 able to represent physical domains to solve planning and scheduling problems. DDL.1 uses a representation, inspired by classical control theory, based on state-variables to represent the relevant features of a domain. Each state variable is meant to represent a set of plausible temporal evolutions those features may have. DDL.1 allows to ...

D-alanine: D-alanine ligase (DDL) is a vital enzyme in the bacterial cell wall biosynthesis. It is involved in the synthesis of D-alanine dipeptide which crosslinks the peptidoglycan for integrity. In this study, the 3Dimensional structure of theDDL of Enterococcus faecalis (E.faecalis) was determined through Homology Modeling, on the basis of crystal structure coordinates of DDL of Staphylococ...

The last decade of basic research in the area of Description Logics (DL) has created a stable theory, efficient inference procedures, and has demonstrated a wide applicability of DL to knowledge representation and reasoning. The success of DL in the semantic web and the distributed nature of the last one inspired recently a proposal of Distributed DL framework (DDL). DDL is composed of a set of...

The dynamic description logic DDL provides a kind of action theories based on description logics (DLs). Compared with another important DL-based action formalism constructed by Baader et.al., a shortcoming of DDL is the absence of occlusions and conditional postconditions in the description of atomic actions. In this paper, we extend atomic action definitions of DDL to overcome this limitation....