Some years ago, Silvestre and Gallai (1968) successfully treated gonorrhoea in men using doxy-cycline HC1 given in a single oral dose. In Glasgow comparable results were obtained in the treatment of gonorrhoea in women by Moffett, McGill, Masterton, and Schofield (1972), as well as in men by Masterton and Schofield (1972). Furthermore, a significant number of male patients who were suffering fr...

One titrimetric and two indirect spectrophotometric methods are described for the determination of doxycycline hyclate (DCH) in bulk drug and in its formulations. The methods use bromate-bromide, methyl orange and indigo carmine as reagents. In titrimetry (method A), DCH is treated with a known excess of bromate-bromide mixture in acid medium and the residual bromine is back titrated iodometric...

One of the disadvantages gel preparations is poor ability to penetrate skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based containing microparticle doxycycline hyclate (DOX). Oleic acid (OA) was added into formulation specifically increase penetrability DOX microparticles. The objective this work determine effect varying concentration OA on physical characteristics, penetra...

methylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride hemiethanol hemihydrate (Fig. 1), is one of the tetracycline derivatives, which has a wide range of antibacterial activities. DOX is frequently used to treat chronic prostatitis, sinusitis, syphilis, chlamydia, pelvic inflammatory disease, acne, rosacea, and rickettsia...

Smart antibacterial materials capable of releasing antibiotic drugs upon exposure to external triggers are highly desired for various medical applications. Herein, the fabrication thermosensitive drug-loaded core−shell nanofibers using electrospinning technique combined with in situ UV photopolymerization is reported on. The method used shaping core structure comprising biodegradable polymer po...