The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tis...

The mechanism of topically applied methyl nicotinate-induced local cutaneous erythema was studied in normal human subjects. Aqueous methyl nicotinate (0, 0.1, 1.0, 10.0, and 100 mmol/L) was applied to the volar forearms in quadruplicate after oral pretreatments with 25 mg doxepin hydrochloride, 600 mg ibuprofen, 50 mg indomethacin, 975 mg aspirin, and lactose placebo. The cutaneous vascular res...

Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug be administers directly into the blood flow Buccal mucosa through using fast dissolving movie system. The main aim study was formulate and evaluate Doxepin by buccal film. film were prepared solvent casting method d...

The crystal structure of ( E )-doxepin hydrochloride has been solved and refined using synchrotron X-ray powder diffraction data, optimized density functional techniques. crystallizes in space group P 2 1 / a (#14) with = 13.78488(7), b 8.96141(7), c 14.30886(9) Å, ? 96.5409(5)°, V 1756.097(12) Å 3 , Z 4. There is strong discrete hydrogen bond between the protonated nitrogen atom chloride anion...

BACKGROUND The literature on chronic idiopathic urticaria (CIU) lacks large-scale population-based studies. OBJECTIVE To characterize an insured population with CIU, including their demographic characteristics and comorbidities. METHODS We conducted a cross-sectional analysis using insurance claims. We included patients with 1 outpatient claim with an International Classification of Disease...