Myostatin, a member of the transforming growth factor-beta superfamily, is a negative regulator of skeletal muscle growth. Cattle with mutations that inactivate myostatin exhibit a remarkable increase in mass of skeletal muscle called double muscling that is accompanied by an equally remarkable decrease in carcass fat. Although a mouse knockout model has been created which results in mice with ...

The objective of this work was to determine the effect of sex, breed and birth season of calves on intensity of MLLT (musculus longissimus lumborum et thoracis) area changes and development of the selected body parts in bulls and heifers of Blonde d´Aquitaine (BA) cattle during rearing period. Two generations of bulls (n=63) and heifers (n=68) of Blonde d´Aquitaine (n=61) and crossbreds C×BA (C...

The aim of this experiment was to evaluate the impact of selection for greater muscling on whole body insulin responsiveness in cattle, as reflected by greater uptake of glucose in response to constant insulin infusion and greater glucose disappearance following an intravenous glucose tolerance test. This study used 18-month-old steers from an Angus herd visually assessed and selected for diver...

Phenotypic expression of dairy influence often carries negative implications in beef production; thus, considerable variation beef- versus dairy-type might adversely affect value crossbred × cattle. This study evaluated effects phenotype cattle, specifically that associated with dairy-type, on meat quality. Effects were blocked within commercial feedlot pens because cattle a pen contemporaries ...

Excessive muscling in double-muscled cattle arises from mutations in the myostatin gene, but the role of myostatin in normal muscle development is unclear. The aim of this study was to measure the temporal relationship of myostatin and myogenic regulatory factors during muscle development in normal (NM)- and double-muscled (DM) cattle to determine the timing and possible targets of myostatin ac...