Case Age at Cause of No. Onset Sex Ophthalmoplegia Manifestation (yrs) 1 47 F S u b a r a c h no i d !Fuchs's phenomenon of lid retraction on adduction haemorrhage Pseudo-Graefe phenomenon of lid retraction on looking down 2 i F Typhoid Paradoxical retraction on occlusion of sound eye 3 5 M Head injury Lid retraction on attempted adduction Pseudo-Graefe phenomenon of lid retraction on looking d...

Chronic dopamine replacement therapy in Parkinson's disease (PD) leads to deleterious motor sequelae known as L-DOPA-induced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [(±)propranolol], a nonselective β-adrenergic receptor (βAR) antagonist, may reduce LID. The present study used the rat unilat...

Murine double minute 4 protein (MDMX) is crucial for the regulation of the tumor suppressor protein p53. Phosphorylation of the N-terminal domain of MDMX is thought to affect its binding with the transactivation domain of p53, thus playing a role in p53 regulation. In this study, the effects of MDMX phosphorylation on the binding of p53 were investigated using molecular dynamics simulations. It...

He was taken to hospital and did not recover consciousness for five days. XVhen he came to, he noticed that he could not open his left eye. There was no other paralysis but he was told that he had had a temporary left sided hemiplegia for the first three days. He noticed that when he lifted the left upper lid with his hand he saw double, The diagnosis was fracture of base of skull, nasal bones ...

In concept learning, inductive techniques perform a global approximation to the target concept. Instead, lazy learning techniques use local approximations to form an implicit global approximation of the target concept. In this paper we present C-LID, a lazy learning technique that uses LID for generating local approximations to the target concept. LID generates local approximations in the form ...

AIM To demonstrate the efficacy of a petrolatum based calcium ointment applied to the lower lid skin in the management of dry eye. METHODS In a controlled double masked study, the effects of water free petrolatum ointment containing calcium carbonate (10% w/w) on tear functional factors and ocular surface vital staining in dry eye patients were observed. Petrolatum without calcium carbonate s...

Levodopa remains the mainstay of treatment for Parkinson disease (PD), but its use is associated with dyskinesias (LID) in many patients. LID likely reflect dysregulated release of dopamine combined with altered postsynaptic mechanisms due to pulsatile dopamine receptor stimulation. Dopamine D receptors are increased in animal models of LID, and experimental LID is attenuated by suppression of ...

BACKGROUND Medical treatment of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is an unmet need. ADS-5102 (amantadine) extended-release capsules is being developed for the treatment of LID in patients with PD. OBJECTIVE Evaluate the long-term safety and tolerability of 274 mg ADS-5102 for LID in PD. METHODS In an ongoing, open-label safety study (NCT02202551), PD patients wit...